Optimisation of a Cytogenetic Sample Preparation Procedure for <i>In Vivo</i> Metaphase Analysis of Mammalian Bone Marrow Cells

Optimisation of a Cytogenetic Sample Preparation Procedure for <i>In Vivo</i> Metaphase Analysis of Mammalian Bone Marrow Cells

INTRODUCTION. Metaphase analysis is used to assess the mutagenicity of medicines, and its accuracy depends directly on the quality of cytogenetic preparations. Existing procedures for cytogenetic sample preparation require optimisation because of their time and labour intensiveness and potential for...

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Bibliographic Details
Main Authors: A. O. Verner, T. M. Ustinova, N. G. Vengerovich
Format: Article
Language:Russian
Published: Federal State Budgetary Institution ‘Scientific Centre for Expert Evaluation of Medicinal Products’ of the Ministry of Health of the Russian Federation (FSBI ‘SCEEMP’) 2024-07-01
Series:Регуляторные исследования и экспертиза лекарственных средств
Subjects:
metaphase analysis
chromosomes
metaphase plate
cytogenetic preparations
chromosomal aberrations
bone marrow cells
sample preparation procedure
preclinical studies
rats
<i>in vivo</i>
sample preparation
Online Access:https://www.vedomostincesmp.ru/jour/article/view/618
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https://www.vedomostincesmp.ru/jour/article/view/618

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