Inhibition of KU70 and KU80 by CRISPR interference, not NgAgo interference, increases the efficiency of homologous recombination in pig fetal fibroblasts

Inhibition of KU70 and KU80 by CRISPR interference, not NgAgo interference, increases the efficiency of homologous recombination in pig fetal fibroblasts

Non-homologous end-joining (NHEJ) is a predominant pathway for the repair of DNA double-strand breaks (DSB). It inhibits the efficiency of homologous recombination (HR) by competing for DSB targets. To improve the efficiency of HR, multiple CRISPR interference (CRISPRi) and Natronobacterium gregoryi...

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Main Authors: Guo-ling LI, Rong QUAN, Hao-qiang WANG, Xiao-fang RUAN, Jian-xin MO, Cui-li ZHONG, Hua-qiang YANG, Zi-cong LI, Ting GU, De-wu LIU, Zhen-fang WU, Geng-yuan CAI, Xian-wei ZHANG
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2019-02-01
Series:Journal of Integrative Agriculture
Subjects:
homologous recombination
non-homologous end-joining
CRISPRi
NgAgoi
KU70
KU80
Online Access:http://www.sciencedirect.com/science/article/pii/S2095311918621501
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