BMSC exosomes deliver JKAP to restore Th17/Treg balance via AKT/ERK, alleviating rheumatoid arthritis

BMSC exosomes deliver JKAP to restore Th17/Treg balance via AKT/ERK, alleviating rheumatoid arthritis

Summary: JKAP regulates T cell immunity and inflammation in autoimmune diseases. This study investigates how bone marrow mesenchymal stem cell (BMSC)-derived exosomes deliver JKAP to restore Th17/Treg balance in rheumatoid arthritis (RA). RA CD4+ T-cells and fibroblast-like synoviocytes (RA-FLS) wer...

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Bibliographic Details
Main Authors: Fang-Tian Xu, Yu Ling, Hui-Xian Wei, Lingzhang Meng, Dong Yin, Zhong-Hong Lai, Yu Huang, Xiao Huang, Hai-Ye Li, Qin-Wen Luo, Jian Song, Qiang Tang, Hong-Mian Li
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:iScience
Subjects:
Immunology
Immunity
Cell biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004225010934
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http://www.sciencedirect.com/science/article/pii/S2589004225010934

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