Red pulp macrophages clear parasites, while marginal metallophilic and marginal zone macrophages support CD4+ T cell activation during Plasmodium yoelii infection

Red pulp macrophages clear parasites, while marginal metallophilic and marginal zone macrophages support CD4+ T cell activation during Plasmodium yoelii infection

Malaria, caused by the parasite Plasmodium spp., remains the most prevalent and dangerous vector-borne infectious disease worldwide. Effective pathogen clearance during malaria hinges on the interplay between adaptive and innate immune responses, especially on T cells, B cells, antigen-presenting ce...

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Bibliographic Details
Main Authors: Julia Falkenstein, Anne Ninnemann, Matthias Hose, Abdelrahman Elwy, Karl S. Lang, Kai Matuschewski, Jan Buer, Astrid M. Westendorf, Wiebke Hansen
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Immunology
Subjects:
splenic macrophages
Plasmodium yoelii
parasite clearance
T cell responses
malaria immunity
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1607201/full
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