mPEG-PCL Nanoparticles to Improve Oral Bioavailability of Acalabrutinib: Effect of Polymer Lipophilicity and Hydrophilicity on Physicochemical Properties and In Vivo Performance in Rats

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mPEG-PCL Nanoparticles to Improve Oral Bioavailability of Acalabrutinib: Effect of Polymer Lipophilicity and Hydrophilicity on Physicochemical Properties and In Vivo Performance in Rats

<b>Background/Objectives:</b> This research focuses on the development and optimization of polymer–lipid hybrid nanoparticles (PLHNs) using two grades of mPEG-PCL co-polymers in combination with DPPC and lecithin to address the biopharmaceutical challenges of acalabrutinib (ACP), a selec...

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Bibliographic Details
Main Authors:	Swagata Sinha, Punna Rao Ravi, Sahadevan Rajesh Rashmi, Łukasz Szeleszczuk
Format:	Article
Language:	English
Published:	MDPI AG 2025-06-01
Series:	Pharmaceutics
Subjects:	co-polymerization amphiphilic co-polymer central composite design nanoparticles oral pharmacokinetics
Online Access:	https://www.mdpi.com/1999-4923/17/6/774
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