Single-cell and spatial analyses of the GDF family in tumors, with a focus on the prognostic and biological role of GDF15 in hepatocellular carcinoma

Single-cell and spatial analyses of the GDF family in tumors, with a focus on the prognostic and biological role of GDF15 in hepatocellular carcinoma

Abstract Growth differentiation factors (GDFs) are a subfamily of the TGF-β superfamily whose expression increases in response to cellular stress and disease. Despite emerging cell- or animal-based evidence supporting an association between the GDF subfamily and cancer, systematic pan-cancer analyse...

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Main Authors: Xiaoqian Feng, Qian Huai, Fumin Zhang, Wenkang Yuan, Xingyu Li, Zhuo Yu, Hao Zhang, Yaoling Zhu, Xu Zhang, Baole Tao, Ying Dai, Yishan Du
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Cell & Bioscience
Subjects:
Growth differentiation factors subfamily
Growth differentiation factor15
Diagnosis
Prognostic biomarker
Immune infiltration
Clinical significance
Online Access:https://doi.org/10.1186/s13578-025-01431-9
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https://doi.org/10.1186/s13578-025-01431-9

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