Application of humanized mice in the safety experiments of antibody drugs

Abstract Therapeutic antibodies are valued for their high specificity and selectivity in immunotherapy. However, the potential toxicity they may elicit underscores the necessity of assessing their preclinical efficacy and safety using suitable animal models. In this context, we review the various ca...

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Bibliographic Details
Main Authors: Zhimin Sun, Mengyun Gu, Zixuan Yang, Lei Shi, Liyuan Zhao, Minhui Zheng, Yan Wang, Wei Zhang, Kexin Han, Naping Tang
Format: Article
Language:English
Published: Wiley 2025-06-01
Series:Animal Models and Experimental Medicine
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Online Access:https://doi.org/10.1002/ame2.12562
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