Inactivity-induced NR4A3 downregulation in human skeletal muscle affects glucose metabolism and translation: Insights from in vitro analysis

Inactivity-induced NR4A3 downregulation in human skeletal muscle affects glucose metabolism and translation: Insights from in vitro analysis

Objective: Physical activity promotes health, whereas inactivity is associated with metabolic impairment. The transcription factor nuclear receptor subfamily 4 group A member 3 (NR4A3) is a pleiotropic regulator of skeletal muscle exercise adaptation and metabolism. However, the consequence of lower...

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Bibliographic Details
Main Authors: Jonathon A.B. Smith, Brendan M. Gabriel, Aidan J. Brady, Ahmed M. Abdelmoez, Mladen Savikj, Shane C. Wright, Stefania Koutsilieri, Romain Barrès, Volker M. Lauschke, Anna Krook, Juleen R. Zierath, Nicolas J. Pillon
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Molecular Metabolism
Subjects:
Skeletal muscle
Inactivity
Metabolism
Mitochondria
Protein synthesis
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877825001073
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http://www.sciencedirect.com/science/article/pii/S2212877825001073

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