Acquisition of FGFR1 and NSD3 Amplifications During the Transformation of EGFR-Mutated Lung Adenocarcinoma into Squamous Cell Carcinoma: A Case Report

Acquisition of FGFR1 and NSD3 Amplifications During the Transformation of EGFR-Mutated Lung Adenocarcinoma into Squamous Cell Carcinoma: A Case Report

Histologic transformation from adenocarcinoma to SCLC is a recognized mechanism of resistance in lung cancer. However, the transformation into squamous cell carcinoma is less common, and the associated genomic alterations remain unclear. Here, we present a case of lung adenocarcinoma harboring an EG...

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Main Authors: Naoki Fukunaga, MD, Hideki Terai, MD, PhD, Rui Nomura, MD, Yutaka Kurebayashi, MD, PhD, Kohei Nakamura, MD, PhD, Ryutaro Kawano, MD, Kohei Shigeta, MD, PhD, Koji Okabayashi, MD, Katsuhito Kinoshita, MD, Akihiko Ogata, MD, Lisa Shigematsu, MD, Fumimaro Ito, MD, Hatsuyo Takaoka, MD, Takahiro Fukushima, MD, Shigenari Nukaga, MD, PhD, Keiko Ohgino, MD, PhD, Hiroyuki Yasuda, MD, PhD, Hiroshi Nishihara, MD, PhD, Yuko Kitagawa, MD, PhD, Koichi Fukunaga, MD, PhD
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:JTO Clinical and Research Reports
Subjects:
EGFR mutation–positive lung adenocarcinoma
Squamous cell transformation
NSD3 amplification
FGFR1 amplification
Case report
Online Access:http://www.sciencedirect.com/science/article/pii/S2666364325000797
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