Prognostic impact of clinical and genetic factors on delayed elimination of methotrexate in children with acute lymphoblastic leukemia
Background. Methotrexate (MTX) in high doses (1000–5000 mg/m2), occupies one of the leading places in modern programs of therapy of acute lymphoblastic leukemia (ALL) in children. Achievement of high long-term survival rates in children with ALL has become possible thanks to this drug. However, no l...
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Main Authors: | O. D. Gurieva, M. I. Savelyeva, T. T. Valiev, S. R. Varfolomeeva, M. V. Ilyin |
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Format: | Article |
Language: | Russian |
Published: |
LLC “Publisher OKI”
2025-01-01
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Series: | Фармакокинетика и Фармакодинамика |
Subjects: | |
Online Access: | https://www.pharmacokinetica.ru/jour/article/view/436 |
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