Prognostic impact of clinical and genetic factors on delayed elimination of methotrexate in children with acute lymphoblastic leukemia

Background. Methotrexate (MTX) in high doses (1000–5000 mg/m2), occupies one of the leading places in modern programs of therapy of acute lymphoblastic leukemia (ALL) in children. Achievement of high long-term survival rates in children with ALL has become possible thanks to this drug. However, no l...

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Bibliographic Details
Main Authors: O. D. Gurieva, M. I. Savelyeva, T. T. Valiev, S. R. Varfolomeeva, M. V. Ilyin
Format: Article
Language:Russian
Published: LLC “Publisher OKI” 2025-01-01
Series:Фармакокинетика и Фармакодинамика
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Online Access:https://www.pharmacokinetica.ru/jour/article/view/436
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