Design and Synthesis of E7820/Tasisulam Hybrids as Potential DCAF15 Binders

Design and Synthesis of E7820/Tasisulam Hybrids as Potential DCAF15 Binders

We describe the design and synthesis of a series of N-[arylsulfonyl]-1H-pyrrole-2-carboxamides as hybrid analogs of the DCAF15 binders E7820 and tasisulam, two representative SPLAMs (sulfonamide-containing molecular glues). These hybrid molecules were designed to combine the key interactions of both...

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Bibliographic Details
Main Authors: Sofiane Hocine, Victor Cosson, Remi Calandrino, Timea Baló, Jayson Alves Bordelo, Sébastien Triboulet, Laure Caruana, Laurence Klipfel, Sandrine Calis, András Herner, Stephen Hanessian
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Reactions
Subjects:
molecular glues
DCAF15 binders
hybrid molecules
Online Access:https://www.mdpi.com/2624-781X/6/2/34
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