The small GTPase ARF6 regulates sphingolipid homeostasis and supports proliferation in acute myeloid leukemia

The small GTPase ARF6 regulates sphingolipid homeostasis and supports proliferation in acute myeloid leukemia

Metabolic dependencies are emerging as promising therapy targets in cancer, including acute myeloid leukemia (AML). Several metabolic vulnerabilities have been identified in AML cells, including a requirement for balanced sphingolipid metabolism to maintain survival and proliferation. Here we descr...

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Main Authors: Helong Gary Zhao, Nataly Cruz-Rodriguez, Kent C. Johnson, Anthony D. Pomicter, Briana Bates, Benjamin Bateman, Torsten Haferlach, Tongjun Gu, Jonathan Ahmann, Dongqing Yan, Greg S. Lee, Weiquan Zhu, Jenna Bishop, Shannon J. Odelberg, Michael W. Deininger
Format: Article
Language:English
Published: Ferrata Storti Foundation 2025-07-01
Series:Haematologica
Online Access:https://haematologica.org/article/view/12164
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https://haematologica.org/article/view/12164

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