Synthesis and cytotoxic activity investigations of DNA-tropic 4-dimethylaminostyryl derivatives of N-methyl-pyrimidobenzimidazolium iodides

Synthesis and cytotoxic activity investigations of DNA-tropic 4-dimethylaminostyryl derivatives of N-methyl-pyrimidobenzimidazolium iodides

Introduction. The creation of new compounds with pronounced cytotoxic activity is one of the priority goals in modern medicinal chemistry due to the emergence of multidrug resistance (MDR) to existing chemotherapy drugs for many types of tumour diseases.The objective was the synthesis of DNA-tropic...

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Bibliographic Details
Main Authors: B. V. Paponov, A. N. Sokolova, P. S. Zdereva, S. A. Tsymbal, O. S. Shemchuk, D. N. Maystrenko, O. E. Molchanov, K. N. Semenov
Format: Article
Language:Russian
Published: Academician I.P. Pavlov First St. Petersburg State Medical University 2024-12-01
Series:Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова
Subjects:
methine dyes
azoloazines
quaternized nitrogen atom
styryl substituent
cytotoxicity
dna-binding
Online Access:https://www.sci-notes.ru/jour/article/view/1079
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