Spatially resolved proteomics surveys the chemo‐refractory proteins related to high‐grade serous ovarian cancer

Spatially resolved proteomics surveys the chemo‐refractory proteins related to high‐grade serous ovarian cancer

Abstract High‐grade serous ovarian carcinoma (HGSC) is a lethal malignancy characterized by high incidence, mortality, and chemoresistance. However, its molecular drivers are unknown. In this study, spatially resolved proteomics was applied to 1144 formalin‐fixed paraffin‐embedded tissue spots obtai...

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Main Authors: Linyuan Fan, Yi Liu, Haichao Zhou, Yang Feng, Guangyi Jiang, Guixue Hou, Zhihan Cao, Zhiguo Zheng, Lu Sun, Hao Chen, Yuefei Zhang, Weiran Chen, Yun Xi, Benliang Cheng, Qinghai Yang, Yan Ren, Jianqing Zhu, Siqi Liu
Format: Article
Language:English
Published: Wiley 2025-07-01
Series:Clinical and Translational Medicine
Subjects:
drug resistance
formalin‐fixed paraffin‐embedded
high‐grade serous ovarian carcinoma
laser capture microdissection
spatial proteomics
Online Access:https://doi.org/10.1002/ctm2.70422
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https://doi.org/10.1002/ctm2.70422

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