Optimizing standardized lab-grown skin substitutes evidences a proliferation-differentiation switch based on ascorbic acid

Summary: Developing standardized bioengineered constructs that accurately replicate human skin is a largely sought-after goal. Pathways initiated at the nurturing interface with the dermal compartment have the potential to modulate the developing epidermal architecture. Here, we identified ascorbic...

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Main Authors: Angie Katherine Molina-Oviedo, Ilaria Sorrentino, Irene Clares-Pedrero, Celina Salamanca-Gonzalez, Eduardo Arevalo-Nuñez de Arenas, Marina S. Mazariegos, Carlos Cabañas, Iria Medraño-Fernandez
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:iScience
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Online Access:http://www.sciencedirect.com/science/article/pii/S2589004225013276
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