Ablation of LAT2 Transporter Causes Intramuscular Glutamine Accumulation and Inhibition of Fasting‐Induced Proteolysis

Ablation of LAT2 Transporter Causes Intramuscular Glutamine Accumulation and Inhibition of Fasting‐Induced Proteolysis

ABSTRACT Background The neutral amino acid transporter SLC7A8 (LAT2) has been described as a key regulator of metabolic adaptation. LAT2 mutations in human populations have been linked to the early onset of age‐related hearing loss and cataract growth. As LAT2 was previously found to be highly expre...

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Main Authors: Meritxell Espino‐Guarch, Susie Shih Yin Huang, Clara Vilches, Esther Prat, Rana El Nahas, Ghalia Missous, Susanna Bodoy, Abbirami Sathappan, Mohammad Ameen Al‐Aghbar, Clara Mayayo, Montse Olivé, Silvia Busquets‐Rius, David Sebastián, Antonio Zorzano, Manuel Palacin, Nicholas vanPanhuys, Virginia Nunes
Format: Article
Language:English
Published: Wiley 2025-06-01
Series:Journal of Cachexia, Sarcopenia and Muscle
Subjects:
ageing
glutamine
LAT2
mTORC1
proteolysis
skeletal muscle
Online Access:https://doi.org/10.1002/jcsm.13847
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https://doi.org/10.1002/jcsm.13847

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