Advances in KEAP1-based PROTACs as emerging therapeutic modalities: Structural basis and progress
Kelch-like ECH-associated protein 1 (KEAP1) functions as a substrate adaptor for the Cullin 3-RING E3 ligase complex, mediating the ubiquitination and subsequent proteasomal degradation of nuclear factor erythroid 2-related factor 2 (NRF2). This regulatory mechanism maintains cellular redox homeosta...
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| Main Authors: | , , , , |
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| 格式: | Article |
| 語言: | 英语 |
| 出版: |
Elsevier
2025-09-01
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| 叢編: | Redox Biology |
| 主題: | |
| 在線閱讀: | http://www.sciencedirect.com/science/article/pii/S2213231725002940 |
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