Selection of an Optimal Metabolic Model for Accurately Predicting the Hepatic Clearance of Albumin-Binding-Sensitive Drugs

Selection of an Optimal Metabolic Model for Accurately Predicting the Hepatic Clearance of Albumin-Binding-Sensitive Drugs

<b>Background/Objectives</b>: Hepatic clearance is important in determining clinical drug administration strategies. Achieving accurate hepatic clearance predictions through in vitro-to-in vivo extrapolation (IVIVE) relies on appropriate model selection, which is a critical step. Althoug...

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Bibliographic Details
Main Authors: Ren-Jong Liang, Shu-Hao Hsu, Hsueh-Tien Chen, Wan-Han Chen, Han-Yu Fu, Hsin-Ying Chen, Hong-Jaan Wang, Sung-Ling Tang
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Pharmaceuticals
Subjects:
hepatic clearance
in vitro-to-in vivo extrapolation (IVIVE)
isolated perfused rat liver (IPRL)
well-stirred model (WSM)
modified well-stirred model (MWSM)
protein binding
Online Access:https://www.mdpi.com/1424-8247/18/7/991
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