Discovery of a novel chalcone-derived covalent Keap1 binder for mitigating cisplatin-induced mitochondrial dysfunction and nephrotoxicity

Discovery of a novel chalcone-derived covalent Keap1 binder for mitigating cisplatin-induced mitochondrial dysfunction and nephrotoxicity

Cisplatin-induced kidney injury (CIKI) is a major adverse effect of this widely used chemotherapy agent. Targeting key events involved in CIKI, such as inflammation, apoptosis, mitochondrial dysfunction and oxidative stress, holds potential for mitigating CIKI and improving patient outcomes. Herein,...

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Bibliographic Details
Main Authors: Yanyan Deng, Leizhi Xu, Zhengtao Jiang, Lin Chen, Guanghao Zhu, Chuting Xu, Xiayan Chu, Lixin Wang, Xiaoting Niu, Ling Chen, Zhangping Xiao, Jing Hu, Guangbo Ge
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Redox Biology
Subjects:
Cisplatin-induced kidney injury (CIKI)
The Keap1-Nrf2 complex
Covalent binder
Nephroprotective mechanism
Mitochondrial dysfunction
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231725002502
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