HDAC6 and USP9X Control Glutamine Metabolism by Stabilizing GS to Promote Glioblastoma Tumorigenesis

HDAC6 and USP9X Control Glutamine Metabolism by Stabilizing GS to Promote Glioblastoma Tumorigenesis

Abstract Glioblastoma (GBM) is the most common and the deadliest brain cancer. Glutamine anabolism mediated by glutamine synthetase (GS) is beneficial for GBM cell growth, especially under glutamine deprivation. However, the molecular mechanism underlying GS homeostasis in GBM remains undisclosed. H...

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Bibliographic Details
Main Authors: Go Woon Kim, Minhae Cha, Hien Thi My Ong, Jung Yoo, Yu Hyun Jeon, Sang Wu Lee, Soo Yeon Oh, Min‐Jung Kang, Youngsoo Kim, So Hee Kwon
Format: Article
Language:English
Published: Wiley 2025-07-01
Series:Advanced Science
Subjects:
glioblastoma
glutamine metabolism
GS
HDAC6
USP9X
Online Access:https://doi.org/10.1002/advs.202501553
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https://doi.org/10.1002/advs.202501553

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