Atp7a deficiency induces axonal and myelin developmental defects in zebrafish via ferroptosis

ATP7A genetic mutations lead to Menkes disease (MD), a hereditary neurodegenerative disorder develops significant metabolic abnormalities including copper deficiency and hypomyelination, and even death before 3 years old. However, the underlying mechanisms remain poorly understood. In this study, a...

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Bibliographic Details
Main Authors: You Wu, Jiahuan Li, Wenya Zhai, Wenye Liu, Hao Wu, Hong Liu, Junxia Min, Fudi Wang, Jing-Xia Liu
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Neurobiology of Disease
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Online Access:http://www.sciencedirect.com/science/article/pii/S0969996125002438
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