Deciphering spatially confined immune evasion niches in osteosarcoma with 3-D spatial transcriptomics: a literature review

Osteosarcoma (OS) is the most common primary malignant bone tumour of childhood, yet five-year survival has plateaued at ~60–70% for localised disease and plunges below 30% once metastasis emerges. Formerly viewed as a cell-intrinsic neoplasm entombed in mineralised bone, OS is now understood as a s...

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Bibliographic Details
Main Authors: Guangqiang Qiu, Yongcheng Tang, Junhui Zuo, Heng Wu, Yongxian Wan
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Oncology
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Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1640645/full
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