The OT-II model reveals dual in vitro and in vivo immunomodulatory properties of CD6 in T cell activation

The OT-II model reveals dual in vitro and in vivo immunomodulatory properties of CD6 in T cell activation

IntroductionCD6 is a signal transducing transmembrane glycoprotein expressed on T-cells and a subset of B and NK cells that has emerged as a promising therapeutic target in autoimmunity and cancer.The extracellular domain of CD6 interacts with endogenous (CD166/ALCAM, Galectins 1 and 3,CD318/CDCP-1...

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Main Authors: Alejandra Leyton-Pereira, Irene Fernández-Delgado, María José Rodríguez-Lagunas, Cristina Català, Sergi Casadó-Llombart, Noa Beatriz Martin-Cofreces, Eugenio Bustos-Morán, Natalia Díaz-Garrido, Marta Consuegra-Fernández, Ana Cristina Calpena, Fernando Aranda, María Velasco-de Andrés, Laura Baldomà, Francisco Sánchez-Madrid, Francisco Lozano
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Immunology
Subjects:
lymphocyte scavenger receptors
lymphocyte activation
CD6 deficiency
immunological synapse
immunomodulation
delayed T cell-mediated hypersensitivity
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1571590/full
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