A TRIM Family-Based Strategy for TRIMCIV Target Prediction in a Pan-Cancer Context with Multi-Omics Data and Protein Docking Integration

A TRIM Family-Based Strategy for TRIMCIV Target Prediction in a Pan-Cancer Context with Multi-Omics Data and Protein Docking Integration

The TRIM CIV subfamily, distinguished by its C-terminal PRY-SPRY domains, constitutes nearly half of the human TRIM family and plays pivotal roles in cancer progression through ubiquitination. Identifying TRIM CIV substrates and interactors has emerged as a critical approach for elucidating tumorige...

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Bibliographic Details
Main Authors: Yisha Huang, Jiajia Xuan, Jiayan Liang, Xixi Liu, Yonglei Luo, Xuejuan Gao, Wanting Liu
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Biology
Subjects:
TRIM family
PPI prediction
cancer
multi-omics
machine learning
protein docking
Online Access:https://www.mdpi.com/2079-7737/14/7/742
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