Synthesis, Characterization, and Biological Activities of Rare Earth Metal Complexes with Gallic Acid

Synthesis, Characterization, and Biological Activities of Rare Earth Metal Complexes with Gallic Acid

This study reports the synthesis and characterization of four novel rare earth-gallic acid complexes, Sm(Gal)<sub>3</sub>·4H<sub>2</sub>O, Eu(Gal)<sub>3</sub>·4H<sub>2</sub>O, Tb(Gal)<sub>3</sub>·4H<sub>2</sub>O, and Dy(Gal)<...

Full description

Saved in:
Bibliographic Details
Main Authors: Nguyen Thi Hien Lan, Hoang Phu Hiep, Dinh Cong Trinh, Pham Van Khang
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Inorganics
Subjects:
rare earth metal
gallic acid
antibacterial activity
Vietnam
anti-cancer activity
Online Access:https://www.mdpi.com/2304-6740/13/6/180
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:This study reports the synthesis and characterization of four novel rare earth-gallic acid complexes, Sm(Gal)<sub>3</sub>·4H<sub>2</sub>O, Eu(Gal)<sub>3</sub>·4H<sub>2</sub>O, Tb(Gal)<sub>3</sub>·4H<sub>2</sub>O, and Dy(Gal)<sub>3</sub>·4H<sub>2</sub>O. These complexes were synthesized under optimized conditions (60 °C, pH 4–5) and characterized using the Ln<sup>3+</sup> elemental content method, infrared spectroscopy (FT-IR), thermogravimetric analysis (TGA), mass spectrometry (MS), and fluorescence spectroscopy. IR spectra confirmed the coordination of rare earth ions (Ln<sup>3+</sup>) with gallic acid through carboxylate oxygen atoms. TGA revealed the thermal decomposition pathways, while MS identified the molecular ion peaks and fragmentation patterns. All complexes exhibited strong luminescence under UV excitation, with emission peaks corresponding to characteristic transitions of Sm<sup>3+</sup>, Eu<sup>3+</sup>, Tb<sup>3+</sup>, and Dy<sup>3+</sup>. Biological assays demonstrated significant antimicrobial activity against <i>Escherichia coli</i>, <i>Staphylococcus aureus</i>, and <i>Pseudomonas aeruginosa</i>, with Dy(Gal)<sub>3</sub>·4H<sub>2</sub>O showing the highest efficacy. Additionally, the complexes displayed inhibitory effects on MCF7 breast cancer cells, with Tb(Gal)<sub>3</sub>·4H<sub>2</sub>O exhibiting the lowest IC<sub>50</sub> value (11.3 µM). These findings suggest that rare earth metal complexes with gallic acid have potential applications in biomedical fields, particularly as antimicrobial and anticancer agents.
ISSN:2304-6740

Similar Items