Current status of developments in the field of respiratory syncytial virus vaccines
Respiratory syncytial virus (RSV) is the leading cause of upper respiratory tract infections in children and the elderly. The only specific treatment approved for RSV is the monoclonal antibody Palivizumab for passive immunoprophylaxis in high-risk infants. Sixty years after the virus was discovered...
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| Format: | Article |
| Language: | Russian |
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Central Research Institute for Epidemiology
2025-05-01
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| Series: | Журнал микробиологии, эпидемиологии и иммунобиологии |
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| Online Access: | https://microbiol.crie.ru/jour/article/viewFile/18831/1595 |
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| Summary: | Respiratory syncytial virus (RSV) is the leading cause of upper respiratory tract infections in children and the elderly. The only specific treatment approved for RSV is the monoclonal antibody Palivizumab for passive immunoprophylaxis in high-risk infants. Sixty years after the virus was discovered, several safe RSV vaccine candidates have been licensed. This was facilitated by research to identify the structure of RSV, to study the basic functions of RSV components as well as the mechanisms of innate and acquired immune responses to infection. The negative result of a clinical trial of formalin-inactivated RSV vaccine in children, which resulted in the death of several vaccinated individuals, was taken into account.
The aim of the study was to summarize data from studies of RSV vaccine candidates in laboratory animals and in clinical trials on different age groups.
Articles for the analysis of preclinical and clinical trials of RSV vaccines were found, using the PubMed search engine with “respiratory syncytial virus and vaccine” as the keywords. The selection criteria were that original articles should contain information on preclinical and clinical studies, the latter including phase I–IV randomized controlled trials. From 1967 to the present year, 296 articles summarizing data from studies of RSV vaccine candidates and 1788 articles summarizing data from animal trials of vaccine candidates were found. The review summarizes data from preclinical studies of vaccine candidates and their developers, vaccine formulations, animal models on which the studies were conducted, as well as a brief description of the main findings. Data on clinical trials of vaccine candidates are presented, including target populations, clinical trial number and sources where the results of these trials were published. |
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| ISSN: | 0372-9311 2686-7613 |