Résultats de la recherche - transcriptomics*

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In this study, we investigated the dynamic changes in muscle lipid content (MLC) deposition in the breast muscle of Jingyuan chickens at different stages (42-, 126-, and 180- days old) using metabolomics. The pH_45min, a*, and L* were significantly increased in the breast muscl...

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A deeper understanding of the cellular and molecular pathology pathways of renal fibrosis in lupus nephritis (LN) is essential for the accurate disease assessment and the development of novel therapeutic strategies. In this study, we employed advanced spatial transcriptomics technique to elucidate t...

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Chenbin Zhang,1 Fang Chen,2 Yu Jiang,2 Jun Deng,1 Xiao Yan,1 Xin Yin,1 Bowu Su,1 Wen Liu1 1Department of Pharmacy, The First Hospital Affiliated with Hunan Normal University (Hunan Provincial People’s Hospital), Changsha, 410005, People’s Republic of China; 2Institute of Emergency Medicine, Departme...

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Pseudomonas aeruginosa biofilms cause severe infections in the airways of patients suffering from cystic fibrosis (CF) that are difficult to eradicate, even with intensive antibiotic therapy. The main goal of this study was to define the dual transcriptional response associated with the formation of...

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<b>Background</b>: Yiqi Zengmian (YQZM) functions as an immunopotentiator by enhancing both cellular and humoral immunity. However, its pharmacodynamic active constituents, particularly those absorbed into the bloodstream, and mechanism of action remain unclear. This study aimed to inves...

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IntroductionPrimary dysmenorrhea (PD) is characterized by pain during the menstrual cycle, affects women's health. Our group developed a traditional Chinese medicine plaster (Wentong plaster, WTT) for the treatment of PD. However, the underlying mechanisms have not yet been elucidated.MethodsIn...

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Abstract Advances in spatial transcriptomics demand new tools to integrate data across tissue slices and identify consistent spatial domains. We introduce spCLUE, a comprehensive framework combining multi-view graph network, contrastive learning, attention mechanisms, and a batch prompting module to...

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Osteosarcoma (OS) is the most common primary malignant bone tumour of childhood, yet five-year survival has plateaued at ~60–70% for localised disease and plunges below 30% once metastasis emerges. Formerly viewed as a cell-intrinsic neoplasm entombed in mineralised bone, OS is now understood as a s...

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In order to explore the molecular mechanism of alkaloid biosynthesis in lotus leaves, metabolomics and transcriptomics sequencing analyses were performed on mature lotus leaves of ‘Taikong Lian’ (high alkaloid content), ‘Juwuba’ (medium alkaloid content) and ‘Dazu Honglian’ (low alkaloid content) cu...

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BackgroundBetaine is a natural food component that plays an important role in improving body composition, but the details of its effects on adipose tissue remains to be elucidated. Here, we hypothesize that betaine can alleviate obesity-related metabolic disorders, thus gut microbiota, transcriptomi...

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BackgroundPreeclampsia (PE) is a multisystemic pregnancy syndrome that presents in different clinical subtypes. While placental dysfunction is a critical feature of PE, its contribution to different PE subtypes remains unclear. This study aims to use integrated bioinformatics analysis of placental t...

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<b>Background:</b> The skin, a complex organ vital for protecting the body against environmental challenges, undergoes a multifaceted wound healing process involving hemostasis, inflammation, proliferation, and remodeling. The transcription factor FOSL1 has been implicated in various cel...

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IntroductionBletilla striata (Orchidaceae) is a valuable traditional Chinese medicinal plant prized for its dried rhizomes. However, its cultivation faces significant challenges from leaf rust disease caused by Coleosporium bletiae, which causes substantial yield losses.MethodsTo investigate host re...

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Yak (<i>Bos grunniens</i>) meat is popular with a unique flavor and high nutritional value. This study investigated the effects of dietary supplementation with rumen-protected methionine (RPM) on meat quality, fatty acid composition, volatile flavor compounds, and transcriptomics of <...

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<i>Fritillaria thunbergii</i> Miq., a medicinal plant rich in steroidal alkaloids, produces bulbs that clear heat, resolve phlegm, and detoxify. However, excessive yield-oriented cultivation has reduced the number of <i>F. thunbergii</i> plants that meet commercial standards....

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Introduction: Poplar propolis, a traditional Chinese medicine abundant in phenolic acids and flavonoid compounds, demonstrates remarkable anti-inflammatory activity. It is currently widely applied in the pharmaceutical and health product industries for the prevention and adjuvant treatment of variou...

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High atmospheric vapor pressure deficit (VPD) reduces the calcium (Ca) distribution in tomato (Solanum lycopersicum L.) fruits, severely reducing fruit mass. Reducing the VPD or increasing Ca fertilizer is an important measure to improve Ca distribution in fruits. However, the mechanism through whic...

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