Search Results - myocardial perfusion and function in translated hearts

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    Macrophage-Secreted U2AF1 Orchestrates Coronary Artery Angiogenesis to Facilitate Myocardial Infarction Repair Through the Regulation of Yap1 Variable Splicing by Manyu Gong, Haodong Li, Lei Jiao, Tong Liu, Yanwei Zhang, Jie Liu, Siyu Wang, Hao Wang, Dongping Liu, Zhaoyue Li, Zhiyuan Du, Lihua Sun, Lina Xuan, Shihua Lv, Xuewen Yang, Yanying Wang, Yingfeng Tu, Mengmeng Li, Haodi Wu, Xin Li, Xue Feng, Juan Xu, Wenzhi Li, Yong Zhang, Ying Zhang, Baofeng Yang

    Published 2025-07-01
    “…Plasma U2AF1 levels were measured in 70 MI patients, revealing significantly lower levels in individuals with poor coronary collateral vessel (CCV; Rentrop scores 0–1) than in those with good CCV (Rentrop scores 2–3). In both myocardial and hindlimb ischemia mouse models, overexpression of endothelial cell-specific adenoviral overexpression U2AF1 promoted angiogenesis in the heart and hindlimbs and improved cardiac function after MI. …”
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