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  1. 1

    Global and Chinese burden of non-alcoholic fatty liver disease in chronic liver disease: Findings from the Global Burden of Disease Study 2021 by Xinyu Zhao, Dong Xu, Wei Ji, Zhengzhao Lu, Cheng Huang, Jingjie Zhao, Tingting Xiao, Dongxu Wang, Yuanyuan Kong, Jidong Jia, Hong You, Yuanyuan Ji

    Published 2025-07-01

    Abstract. Background:. Chronic liver disease (CLD), mainly non-alcoholic fatty liver disease (NAFLD), is a significant public health concern worldwide. This study aims to quantify the burden of NAFLD in CLD globally and within China, using data from the Global Burden of Disease (GBD) Study 2021, pr...

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    Sustained Molecular Allograft Injury After Episodes of Acute Rejection and Organizing Pneumonia Increases the Risk of Lung Allograft Failure by Michael B. Keller, MD, Allison Y. Lin, Moon Kyoo Jang, PhD, Hyesik Kong, PhD, Ananth Charya, MD, Gerald J. Berry, MD, Charles C. Marboe, MD, Ileana L. Ponor, MD, MBA, Shambhu Aryal, MD, Jonathan B. Orens, MD, Pali D. Shah, MD, Steven D. Nathan, MD, Xin Tian, PhD, Sean Agbor-Enoh, MD, PhD

    Published 2025-07-01

    Background. Despite treatment of major risk factors such as acute rejection (AR) and organizing pneumonia (OP) in lung transplant recipients, chronic lung allograft dysfunction (CLAD) still develops at high rates, suggesting that traditional methods of assessing response to treatment and resolution...

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    Single-cell RNA sequencing in tuberculosis: Application and future perspectives by Yuejuan Zhan, Qiran Zhang, Wenyang Wang, Wenyi Liang, Chengdi Wang, Peifang Wei

    Published 2025-07-01

    Abstract. Tuberculosis (TB) has one of the highest mortality rates among infectious diseases worldwide. The immune response in the host after infection is proposed to contribute significantly to the progression of TB, but the specific mechanisms involved remain to be elucidated. Single-cell RNA sequ...

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    Establishing and Validating a Biomolecular Signature of Ischemia/Reperfusion Injury in a Porcine Pancreas Allotransplantation Model by Samrat Ray, MBBS, Sujani Ganesh, MSc, Laura Martinez-Arenas, MSc, Catherine Parmentier, MD, Masataka Kawamura, MD, PhD, Bhranavi Arulratnam, MSc, Christian Hobeika, MD, PhD, Emmanuel Nogueira, MD, Francisco Calderon Novoa, MD, Markus Selzner, MD, Trevor W. Reichman, MD, PhD

    Published 2025-08-01

    Background. Despite considerable advancement in surgical and immunological management in pancreas transplantation, graft pancreatitis remains a feared complication after pancreas transplantation. Identification of molecular mechanisms of underlying ischemia/reperfusion injury (IRI) in pancreas trans...

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    Enabling Exploration: Examining the Availability and Adequacy of Conference Funding for Medical Students by Sophia G. Allison, BA, Hannah Soltani, BA, Emily S. Chwa, MD, Dana W. Shuaibi, Kevin R. Allison, Arun K. Gosain, MD

    Published 2025-07-01

    Background:. Due to limited funding available for students to attend conferences, we performed a comprehensive review of publicly provided information regarding medical school funding for academic conferences and surveyed medical students to assess accessibility and adequacy of funding. Methods:. Th...

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    Fibromyalgia: do I tackle you with complementary medicines? by Julien Nizard, Françoise Laroche, Fabrice Berna

    Published 2025-08-01

    Abstract. Recent guidelines for managing fibromyalgia highlight the importance of a graded-care approach, tailoring treatment to predominant symptoms, and appropriately integrating nonpharmacological treatments and complementary medicine (CM). Many fibromyalgia patients turn to nonpharmacological tr...

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    Lower 1-Year PROM Completion Rates and Need for Intensive Follow-Up in Inpatient Medicare THA Patients: Implications for the CMS PROM Policy by Khaled A. Elmenawi, MD, Ignacio Pasqualini, MD, Shujaa T. Khan, MD, Chao Zhang, MS, Matthew E. Deren, MD, Nicolas S. Piuzzi, MD, Cleveland Clinic Adult Reconstruction Research Group, Kurt P. Spindler, MD, Trevor G. Murray, MD, Robert M. Molloy, MD, Kim L. Stearns, MD, Viktor E. Krebs, MD, Nicholas R. Scarcella, MD, Michael Erossy, MD, Alexander L. Roth, MD, Michael R. Bloomfield, MD, Carlos A. Higuera, MD, John P. McLaughlin, DO, Peter A. Surace, MD

    Published 2025-09-01

    Introduction:. The Centers for Medicare and Medicaid Services (CMS) has mandated the collection and reporting of patient-reported outcome measures (PROMs) in total joint arthroplasty (TJA). However, evidence is lacking in identifying patients who fail to respond to PROM collection efforts. This stud...

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    Osteopathic Representation in Orthopaedic Literature: A 25-Year Analysis of Publication Trends of Former AOA Residency Programs and Osteopathic Medical Schools by Ibraheem Qureshi, BS, Troy B. Puga, DO, Hans Drawbert, MD, Michael E. Muncy, DO, John T. Riehl, MD

    Published 2025-09-01

    Background:. Orthopaedic surgery remains one of the most competitive specialties. Osteopathic candidates have recently matched at lower rates than allopathic students. One disparity that may exist is research, which has become a critical component of candidate applications. The aim of this study was...

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    Plant-based Exosome Injections for Skin Wound Healing: Experimental Study by Noury Adel, MSc, DHM, Nenad Stankovic, DDS, Gerardo Cervantes, MD, Amira Gindi, RNP, Lamiaa Mohamed Shawky, PHD

    Published 2025-07-01

    Background:. This study aimed to evaluate the impact of plant-derived exosome injections on the healing of skin wounds. Methods:. A total of 18 Wistar Albino rats were included and randomly allocated into 2 groups. The first group underwent a scalpel incision on the ventral hand surface without any...

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    The effects and safety of sequential high concentration glycolic acid and trichloroacetic acid chemical peels in skin photo-type IV–VI, a retrospective cross-sectional monocentric... by Frans Maruma, MBChB, DipHivMed, MMed, FCDerm, PhD, Ncoza Dlova, MBChB, FCDerm, PhD, Thabiso R.P. Mofokeng, BSc, MBChB, FCP, MMed, MPhil, Edward Ngwenya, BSC, MBBCh, MMed, FCS, FCPlastSurg

    Published 2025-10-01

    Background:. Melasma is a common chronic form of cutaneous hyperpigmentation, particularly prevalent in individuals with Fitzpatrick skin phototypes IV–VI, and it predominantly affects the facial areas of women. The patients with melasma often experience a significant reduction in quality of life. T...

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    Hydrogel Containing an Oxygen Carrier With Hemoglobin From the Marine Worm Arenicola marina (M101) in the Management of Deep Burns by Ugo Lancien, MD, MSc, Pierre-Joachim Mahe, MD, Aline Lepelletier, MD, Elisabeth Leize-Zal, MD, Laurent Lantieri, MD, PhD, Pierre Perrot, MD, PhD

    Published 2025-07-01

    Summary:. A 34-year-old patient with no medical history was admitted following severe thermal burns (>85% of the body surface area), including deep second- and third-degree injuries. Surgical management aimed to heal the entire upper body (thorax, abdomen, and back) using topical oxygen therapy (...

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    Longitudinal Pulmonary Function After Surgical Treatment of Early-Onset Scoliosis by Scott Yang, MD, Apeksha Gupta, MS, MPH, Michael E. Trask, BS, Natalie M. Maharaj, BS, Anna V. Faino, MS, Sean Pirkle, MD, Kelson Roy Adcock, BS, Jennifer M. Bauer, MS, Burt Yaszay, MD, Gregory Redding, MD

    Published 2025-09-01

    Background:. Longitudinal pulmonary outcomes after surgical treatment of early-onset scoliosis (EOS) are not well reported. This study aims to evaluate change in serial pulmonary function in children with EOS after surgery. Methods:. A retrospective review was performed at a single academic hospital...

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