Résultats de la recherche - Lung function
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Сentral heamodynamic сondition and morphological characteristics of lungs at patients with lung cancer depending on components of the infusion-transfusion therapy.
Publié 2015-12-01“…Despite the large number of studies devoted to the study of the functional state of the cardiovascular and respiratory systems after operations on the lungs, there are still many issues regarding the mechanisms of hemodynamic disorders in the postoperative period. …”Background. Despite the large number of studies devoted to the study of the functional state of the cardiovascular and respiratory systems after operations on the lungs, there are still many issues regarding the mechanisms of hemodynamic disorders in the postoperative period. It stipulates considera...
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162
Сentral heamodynamic сondition and morphological characteristics of lungs at patients with lung cancer depending on components of the infusion-transfusion therapy
Publié 2015-12-01“…Despite the large number of studies devoted to the study of the functional state of the cardiovascular and respiratory systems after operations on the lungs, there are still many issues regarding the mechanisms of hemodynamic disorders in the postoperative period. …”Background. Despite the large number of studies devoted to the study of the functional state of the cardiovascular and respiratory systems after operations on the lungs, there are still many issues regarding the mechanisms of hemodynamic disorders in the postoperative period. It stipulates considera...
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163
Clinical study on modified Shenzhe Zhenqi Decoction combined with ambroxol hydrochloride in the treatment of severe pneumonia
Publié 2025-07-01Sujets: Accéder au texte intégralObjectiveThis study aimed to evaluate the clinical efficacy of modified Shenzhe Zhenqi Decoction combined with ambroxol hydrochloride in treating severe pneumonia.MethodsThis was a single-center, prospective, double-blind, randomized controlled trial. A total of 138 patients with severe pneumonia we...
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Long-term outcomes of the international EXPAND trial of Organ Care System (OCS) Lung preservation for lung transplantationResearch in context
Publié 2025-07-01“…Although this technology is increasingly used in the United States, no published data describe its effects on long-term graft function and patient outcomes. This study assessed long-term clinical outcomes after transplantation of ECD lungs that were preserved, recruited, and assessed with the OCS Lung. …”Summary: Background: Portable ex vivo lung perfusion and ventilation with the Organ Care System (OCS) Lung system is a safe, effective method for preserving extended criteria donor (ECD) organs before transplant. Although this technology is increasingly used in the United States, no published data...
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Alveolar macrophages maintain tissue localization and gain enhanced anti-tumor activity in Lewis lung carcinoma-reprogrammed lung microenvironment
Publié 2025-07-01“…The role of alveolar macrophages (AMs) in lung carcinogenesis has been extensively studied, yielding significant insights. …”The role of alveolar macrophages (AMs) in lung carcinogenesis has been extensively studied, yielding significant insights. However, the status of AMs in tumor-bearing lungs remains incompletely characterized. Using orthotopic Lewis Lung Carcinoma (LLC) mouse models, we found that tumors induced an i...
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166
Dynamic 3D-Network Coating Composite Enables Global Isolation of Phosphopeptides, Stepwise Separation of Mono- and Multi-Phosphopeptides, and Phosphoproteomics of Human Lung Cells
Publié 2025-06-01Sujets: Accéder au texte intégralProtein phosphorylation is one of the most common and important post-translational modifications (PTMs) and is highly involved in various biological processes. Ideal adsorbents with high sensitivity and specificity toward phosphopeptides with large coverage are therefore essential for enrichment and...
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Directed Connectivity Analysis of the Neuro-Cardio- and Respiratory Systems Reveals Novel Biomarkers of Susceptibility to SUDEP
Publié 2020-01-01Sujets: Accéder au texte intégralSudden unexpected death in epilepsy (SUDEP) is the leading cause of epilepsy-related mortality and its pathophysiological mechanisms remain unknown. <italic>Goal:</italic> We set to record and analyze for the first time concurrent electroencephalographic (EEG), electrocardiographic (ECG)...
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Outcome of lung cancer surgery and proportion of lung cancer patients eligible for surgery in five Finnish hospitals in 2018, real world study
Publié 2025-07-01“…Background and purpose: Lung cancer is one of the most common malignancies worldwide and is associated with high mortality. …”Background and purpose: Lung cancer is one of the most common malignancies worldwide and is associated with high mortality. In Finland, overall lung cancer survival is lower than in other Nordic countries. A recent Finnish Cancer Registry publication reported that only 11.8% of patients underwent su...
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Elucidating the Role of FASN in Lung Cancer Stem Cells in Sensitive and Resistant EGFR-Mutated Non-Small Cell Lung Cancer Cells
Publié 2025-05-01“…Our research team developed polycaprolactone electrospun (PCL-ES) scaffolds for enriching lung CSCs (LCSCs) since monolayer culture do not allow the study of this malignant population. …”Emma Polonio-Alcalá,1,2 Sira Ausellé-Bosch,1 Gerard Riesco-Llach,3 Pablo Novales,1 Lidia Feliu,3 Marta Planas,3 Joaquim Ciurana,2 Teresa Puig1 1New Therapeutic Targets Laboratory (Targetslab) – Oncology Unit, Department of Medical Sciences, University of Girona, Girona, Spain; 2Product, Process, and...
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170
Early Use of Surfactant-BL after Lung Transplantation
Publié 2013-04-01“…To evaluate the clinical effect of early administration of surfactant-BL on pulmonary oxygenizing function and biomechanics in patients early after lung transplantation (LT). …”Goal. To evaluate the clinical effect of early administration of surfactant-BL on pulmonary oxygenizing function and biomechanics in patients early after lung transplantation (LT). Materials and methods. Seven patients early after transplantation were administered with a surfactant-BL («Biosurf», St...
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171
Features of surgical treatment of the apical right lung cancer
Publié 2022-06-01“…Taking into account the topical location of the tumor, the greatest technical difficulties during the operation arose when performing mobilization of the upper lobe of the right lung, adequate lymph dissection near large arterial and venous vessels, removal of part of the chest wall of the pleural cavity dome.Also, one of the important issues when planning surgical treatment of this group of patients is to determine the indications for restoring the skeletal function of the chest after rib resection. …”The tumor of the upper sulcus of the lung is an atypical form of cancer, which is characterized by invasion into the aperture of the chest and mediastinum, which in turn determines the manifestation of the disease of neurological symptoms.Tactical approaches in the treatment of this disease are well...
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Comment on &ldquo;Predictive Value of Advanced Lung Cancer Inflammation Index and Development of a Nomogram for Prognosis in Patients with Cervical Cancer Treated with Radiothe...
Publié 2025-07-01Accéder au texte intégralQiong Yu,1 Xin Jin2 1Department of Digestive Medicine, Wuhan Sixth Hospital and Affiliated Hospital of Jianghan University, Wuhan, Hubei, People&rsquo;s Republic of China; 2Department of Clinical Nutrition, Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Tec...
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Diagnosis and treatment of interstitial lung disease in scleroderma systematica
Publié 2018-06-01“…Evaluation of lung damage in SDS includes pulmonary function tests, lung diffusing capacity determination, Doppler echocardiography analysis, multispiral computed tomography (MSCT) of the chest, bronchoalveolar lavage, lung biopsy with morphological examination of its specimens, as well as right heart catheterization. …”Scleroderma systemitica (SDS) is an autoimmune connective tissue disease characterized by excessive fibrosis of the skin and viscera. SDS is prone to be chronic and progressive, is accompanied by the deterioration in quality of life and working ability and has an unfavorable prognosis. Interstitial...
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Lung-resident SARS-CoV-2 peptide-specific immune responses in perfused 3D human lung explant models
Publié 2025-07-01“…IntroductionMulti-specific and long-lasting T-cell immunity has been recognized to indicate long-term protection against pathogens, including the novel coronavirus, SARS-CoV-2, which is the causative agent of the COVID-19 pandemic. Functional significance of peripheral memory T cells in individuals recovered from COVID-19 (COVID-19+) is beginning to be appreciated; however, the role of lung tissue-resident memory (lung TRM) T cells in SARS-CoV-2 infection is still being investigated. …”IntroductionMulti-specific and long-lasting T-cell immunity has been recognized to indicate long-term protection against pathogens, including the novel coronavirus, SARS-CoV-2, which is the causative agent of the COVID-19 pandemic. Functional significance of peripheral memory T cells in individuals...
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Implication of Acute Lung Injury in the Pathogenesis of Hemostatic Disorders
Publié 2008-06-01“…Three groups were identified, which included: 1) 50 patients with an uncomplicated postoperative period and without any organ incompetence; 2) 21 patients with primary lung injury; and 3) 24 patients with secondary lung injury. …”Objective: to estimate the implication of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) in the pathogenesis of hemostatic disorders, by studying the arteriovenous difference between hemostatic parameters. Subjects and methods. Venous and arterial hemostases were studied in 9...
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Minimal Clinically Important Difference for Worsening of the University of California San Diego Shortness of Breath Questionnaire in Patients With Idiopathic Pulmonary Fibrosis With Mild or Moderate Impairment in Lung FunctionTake-Home Points
Publié 2025-09-01“…Previously, the minimal clinically important difference (MCID) for UCSD-SOBQ was estimated at 8 points for patients with IPF with severe impairment as determined by lung function tests. Research Question: What is the MCID threshold for UCSD-SOBQ worsening in patients with IPF and less physiologic impairment? …”Background: The University of California San Diego Shortness of Breath Questionnaire (UCSD-SOBQ) is used commonly in clinical trials to evaluate dyspnea in patients with idiopathic pulmonary fibrosis (IPF). Previously, the minimal clinically important difference (MCID) for UCSD-SOBQ was estimated at...
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Predictors of using extracorporeal membrane oxygenation in lung transplantation
Publié 2019-06-01“…Rationale. Lung transplantation is the only definitive treatment in end-stage pulmonary disease. …”Rationale. Lung transplantation is the only definitive treatment in end-stage pulmonary disease. Extracorporeal membrane oxygenation (ECMO) has been used during surgery in recent years as a replacement for respiratory function; ECMO, however, has some drawbacks: the presence of an extracorporeal cir...
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RITUXIMAB TREATMENT FOR INTERSTITIAL LUNG INJURY IN SCLERODERMA SYSTEMATICA
Publié 2013-12-01“…All the patients underwent chestcomputed tomography; examination of external respiratory function, including forced vital capacity (FVC) and diffusing capacity of the lung (DCL), as well as echocardiographic study. …”Objective: to study the efficiency and tolerance of rituximab (RTM) treatment in patients with scleroderma systematica (SDS) with interstitial lung injury (ILI).Subjects and methods. The trial included 27 patients (26 women and 1 man) (mean age 45.7±13.0 years), with diffuse (n=13) and circumscribed...
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MORPHOFUNCTIONAL STATE OF BUCCAL EPITHELIOCYTES IN LUNG CANCER PATIENTS
Publié 2016-02-01“…Parameters of epitheliocytes in buccal mucosal smears of lung cancer patients were analyzed. The study results showed disturbances in the process of maturation and differentiation of the oral mucosal epithelium, significant structural and functional changes in buccal epitheliocytes, which were more pronounced after chemotherapy…”Parameters of epitheliocytes in buccal mucosal smears of lung cancer patients were analyzed. The study results showed disturbances in the process of maturation and differentiation of the oral mucosal epithelium, significant structural and functional changes in buccal epitheliocytes, which were more...
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Exosome Secretion Regulation in Mice with Acute Lung Injury
Publié 2025-06-01“…Exosomes secreted by lipopolysaccharide—treated rat type II alveolar epithelial cells stimulated the polarization of M1 macrophages, which resulted in morphological and functional changes.Conclusion: Exosome Secretion Regulation in Mice with Acute Lung Injury.Keywords: sepsis, C—C motif chemokine ligand 2, CCL2, exosome, lung macrophages, acute lung injury…”Hui-Hui Jie,1,2 Wei-Hua Lu1,3 1Department of Critical Care Medicine, The First Affiliated Hospital of Wannan Medical College (Yijishan Hospital of Wannan Medical College), Wuhu, Anhui, 241001, People’s Republic of China; 2Graduate School of Wannan Medical University, Wuhu, Anhui, 241001, People’s Re...
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