खोज परिणाम - Lung function
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141
Ejection fraction, B-lines, and global longitudinal strain evaluated with rest transthoracic echocardiography to assess prognosis in patients with chronic coronary syndromes
प्रकाशित 2023-09-01विषय: पूर्ण पाठ प्राप्त करेंAim: Transthoracic echocardiography (TTE) is the first-line imaging test for patients with chronic coronary syndrome (CCS) and the cornerstone of risk stratification is left ventricular (LV) ejection fraction (EF). Aim of the study was to investigate the value of TTE supplemented with strain echocar...
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142
Genetic Regulation of Alternative Polyadenylation Provides Novel Insights into Molecular Mechanisms Underlying Non‐small Cell Lung Cancer
प्रकाशित 2025-07-01विषय: पूर्ण पाठ प्राप्त करेंAbstract Emerging evidence emphasizes the critical role of alternative polyadenylation (APA) in posttranscriptional regulation of genes, and APA‐associated genetic variants (apaQTLs) show particular relevance for multiple disease. However, genetic regulation of APA and its role in non‐small cell lun...
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143
Bronchial complications after lung transplantation
प्रकाशित 2021-04-01“…Light forms decrease transplant function and while progressing can leads to life-threatening conditions without required treatment. …”Bronchial complications are among the main causes of impairing postoperative period and thansplant failure. Severe bronchial complications are very rare but have a high mortality rate. Light forms decrease transplant function and while progressing can leads to life-threatening conditions without req...
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144
Convolutional neural network for IT lung diagnostics
प्रकाशित 2024-05-01“…The purpose of the article is to develop a neural network for the diagnosis of lung diseases using sound analysis of the patient's voice. …”The subject of research is the use of voice processing technology of the patient in IT medicine. The purpose of the article is to develop a neural network for the diagnosis of lung diseases using sound analysis of the patient's voice. The study includes training of a neural network, development...
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145
MULTIFACTORIAL ASSESSMENT OF POSTMORTEM LUNG DONOR
प्रकाशित 2013-03-01“…To develop and determine the effectiveness of the protocol of morpho- functional assessment of potential lung donor. Methods and results. …”The appropriate evaluation and the development of special measures to protect donor lungs are important factors for successful lung transplantation. Aim. To develop and determine the effectiveness of the protocol of morpho- functional assessment of potential lung donor. Methods and results. During t...
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146
Postoperative Prevention of Acute Lung Injury
प्रकाशित 2007-06-01“…Objective: to analyze the tactics of infusion therapy in old age group patients with generalized peritonitis and to search for ways of preventing acute lung injury in the early postoperative period. Subjects and methods. …”Objective: to analyze the tactics of infusion therapy in old age group patients with generalized peritonitis and to search for ways of preventing acute lung injury in the early postoperative period. Subjects and methods. The adequacy of infusion therapy was analyzed in the treatment of 237 patients...
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147
S100a4+ alveolar macrophages accelerate the progression of precancerous atypical adenomatous hyperplasia by promoting the angiogenic function regulated by fatty acid metabolism
प्रकाशित 2025-07-01“…Lung cancer is preceded by premalignant lesions, and what factors drive this transformation and the potential regulatory mode in the context of tumor initiation remain to be elucidated. …”Lung cancer is preceded by premalignant lesions, and what factors drive this transformation and the potential regulatory mode in the context of tumor initiation remain to be elucidated. In the course of precancerous lesions in mice, we found a phasic shift in metabolic patterns. Macrophages are a he...
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148
Mechanisms of Lung Cancer Development in Cystic Fibrosis Patients: The Role of Inflammation, Oxidative Stress, and Lung Microbiome Dysbiosis
प्रकाशित 2025-06-01“…Cystic fibrosis (CF) is a genetic disorder caused by mutations in the CFTR gene, leading to defective ion transport and impaired function of various organs. Chronic inflammation, oxidative stress, and microbial dysbiosis are key pathological features of CF patients, contributing to disease progression, lung damage, and an increased susceptibility to infections. …”Cystic fibrosis (CF) is a genetic disorder caused by mutations in the CFTR gene, leading to defective ion transport and impaired function of various organs. Chronic inflammation, oxidative stress, and microbial dysbiosis are key pathological features of CF patients, contributing to disease progressi...
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149
Inversin correlates with the malignant phenotype of non–small cell lung cancer and promotes the invasiveness of lung cancer cells
प्रकाशित 2017-05-01“…As measured by immunohistochemical staining, inversin was highly expressed in the cytoplasm of lung cancer samples (63.4%, 161/254) compared with adjacent normal lung tissues (22.0%, 11/50, p < 0.01). …”Inversin, encoded by NPHP2, is one of the 10 NPHP proteins known to be involved in nephronophthisis (an autosomal recessive cystic kidney). Although the previous reports showed that inversin played an important role in embryonic development and renal diseases, its function in cancer was not revealed...
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150
From Gut to Lung: The Role of Bile Acids in Rheumatoid Arthritis-Associated Interstitial Lung Disease (RA-ILD)
प्रकाशित 2025-08-01“…By exploring the gut–lung axis and the interactions between bile acid metabolism and immune responses, the review seeks to identify new avenues for RA-ILD treatment. …”Yu-jia Shi,1 Shu Lin,2,3 Yan-Chuan Shi,3,4 Jianmin Xie1 1Department of Rheumatology and Immunology, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, People’s Republic of China; 2Centre of Neurological and Metabolic Research, The Second Affiliated Hospital of Fujian Med...
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151
Fabrication of Carbon Nanodots/Platinum Functionalized Nanocomposite Hydrogel Formulation for Near‐Infrared Responsive Delivery of Doxorubicin to Promote Necroptosis for Mitigating Lung Cancer Cells: In Vitro Photodynamic Therapy
प्रकाशित 2025-07-01पूर्ण पाठ प्राप्त करेंAbstract Lung cancer remains one of the deadliest cancers, marked by uncontrolled cell growth in the lungs and often diagnosed at later stages. This study presents a novel hydrogel‐embedded nanocomposite responsive to Near‐Infrared (NIR) light (CN‐Pt‐DOX@CS+NIR) to induce necroptosis in lung cancer...
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152
Optimization, Characterization and Pharmacological Validation of the Endotoxin-Induced Acute Pneumonitis Mouse Model
प्रकाशित 2025-06-01विषय: “…acute lung injury…”<b>Background/Objectives</b>: In preclinical research of airway inflammation, the endotoxin (lipopolysaccharide: LPS)–induced acute interstitial pneumonitis is the most commonly used mechanism model. However, studies apply different LPS serotypes, doses, administration routes, and refere...
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153
Impact of immunotherapy with autologous activated T-lymphocytes on clinical parameters and quality of life in patients with allergic bronchial asthma
प्रकाशित 2022-04-01विषय: पूर्ण पाठ प्राप्त करेंAim. To assess the impact of autologous activated T-lymphocyte immunotherapy on clinical parameters and quality of life in patients with allergic bronchial asthma (BA) in comparison with patients with allergic BA who received standard therapy.Materials and methods. A non-randomized, pilot study incl...
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154
Exercise Prescription in Lung-Transplanted Cystic Fibrosis Adults
प्रकाशित 2025-06-01“…In the CF group, free fat mass and functional parameters (peak VO2 and VO2/HR) were negatively correlated (r = −0.51 and −0.52, respectively). …”<b>Background</b>: Physical exercise intervention in cystic fibrosis (CF) is of recent interest; however, no specific method to detect improvements in body composition and cardiovascular performance after transplantation has been investigated. This study aims to verify the feasibility of...
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155
Airway cilia recovery post lung transplantation
प्रकाशित 2021-12-01“…Impaired clearance may lead to increased risk of infections and progressive lung damage. Significant morbidity in the immediate post lung transplantation period is associated with airway infection, which we hypothesize may be caused by impaired cilia function. …”Abstract Background Normally functioning airway cilia is essential for efficient mucociliary clearance to protect the airway from various insults. Impaired clearance may lead to increased risk of infections and progressive lung damage. Significant morbidity in the immediate post lung transplantation...
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156
The vascular endothelium as decision maker in lung injury
प्रकाशित 2025-07-01“…This underscores the importance of proper endothelial function for the health of the body’s tissues and organs. …”The vascular endothelium is the largest organ in the human body, capable of performing a wide range of cellular signaling and synthetic functions. It is also subjected to considerable mechanical stress due to the shear forces generated by blood flow, which amounts to approximately 10,000 L per day....
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157
Hydrogel‐embedded precision‐cut lung slices support ex vivo culture of in vivo‐induced premalignant lung lesions
प्रकाशित 2025-07-01“…Abstract Lung cancer is the leading cause of global cancer death, and prevention strategies are key to reducing mortality. …”Abstract Lung cancer is the leading cause of global cancer death, and prevention strategies are key to reducing mortality. Medical prevention of premalignant lesion (PML) progression may have a larger impact than treatment on mortality by targeting high‐risk populations and reducing their lung cance...
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158
Features of cardiac remodeling in sclerodermic lung lesions
प्रकाशित 2016-07-01“…Objective: to examine the relationship between structural and functional heart remodeling and sclerodermic lung disease.Material and methods. …”Objective: to examine the relationship between structural and functional heart remodeling and sclerodermic lung disease.Material and methods. The study involved 62 women: 21 with systemic sclerosis (SSC) (mean age 49,4±2,1 years) and 41 healthy women (mean age 45±1,7 years) (р=0,127). Examination an...
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159
INTERSTITIAL LUNG DISEASE ASSOCIATED WITH SYSTEMIC SCLEROSIS
प्रकाशित 2017-03-01“…Pulmonary functional tests show that relatively preserved and stable forced vital capacity is long recorded in the majority of patients, but the diffusing capacity of the lung is reduced in 70–80% of the patients. …”The basis for the pathogenesis of systemic sclerosis (SS) is immune disorders that initiate inflammation, as well as vasculopathy with obvious microcirculatory disturbances, and generalized fibrosis. In SS, lung injury is due to an arterial lesion and/or a fibrotic process in the lung parenchyma and...
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160
VentilatorInduced Lung Injuries (an Experimental Study)
प्रकाशित 2014-12-01“…The use of PEEP for ARDS was ascertained to improve blood oxygenation due to decreased pulmonary shunt, better respiratory muscle performance, lower infiltrated and atelectatic tissue volumes, and higher lung functional residual capacity…”Objective: to evaluate the impact of highfrequency jet ventilation (HFJV) and traditional positive endexpiratory pressure (PEEP) ventilation on blood oxygenation, gas exchange, and hemodynamics on an experimental model of acute lung injury.Material and methods. Thirty albino outbred laboratory male...
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