Kết quả tìm kiếm - Lung function
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The crucial function of IDO1 in pulmonary fibrosis: From the perspective of mitochondrial fusion in lung fibroblasts and targeted molecular inhibition
Được phát hành 2025-06-01“…Indoleamine 2,3-dioxygenase 1 (IDO1) is expressed in lung fibroblasts and epithelial cells, but its functions in lung homeostasis and diseases remain elusive. …”The pathogenesis of pulmonary fibrosis (PF) is complex. It is characterized by myofibroblast hyperplasia and deposition of collagen protein. Indoleamine 2,3-dioxygenase 1 (IDO1) is expressed in lung fibroblasts and epithelial cells, but its functions in lung homeostasis and diseases remain elusive....
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Anthrahydroquinone-2,6-Disulfonate Restores Lung Function in COPD Through Keap1/Nrf2 Pathway Activation
Được phát hành 2025-07-01Những chủ đề: lấy văn bảnZhao Li,1– 4,* Jun Chen,5,* Jiadong Zhang,1– 3,* Nan Li,1– 3 Yang Yi,1– 3 Hanjing Lu,1– 3 Min Li,1– 3 Rui Liu,1– 3 Yuanpeng Chen,1– 3 Xiaoran Liu1 1College of Emergency Trauma, Hainan Medical University, Haikou, Hainan, People’s Republic of China; 2Key Laboratory...
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Effects of traditional Chinese exercise on lung function and mental health in patients with COPD: a systematic review and meta-analysis
Được phát hành 2025-07-01Những chủ đề: lấy văn bảnObjectiveDespite their widespread use in the management of chronic obstructive pulmonary disease (COPD), pharmacological treatments often demonstrate limited efficacy in alleviating symptoms such as dyspnea and psychological pressure. These limitations highlight the need for complementary nonpharmac...
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Early Onset Asthma, But Not Aeroallergen Sensitization, Is Associated With Lung Function Impairment in Young Adulthood—A Prospective Cohort Study
Được phát hành 2025-07-01“…ABSTRACT Background Aeroallergen sensitization is a major factor in asthma, and asthma is associated with impaired lung function. The independent association between sensitization and lung function is unclear. …”ABSTRACT Background Aeroallergen sensitization is a major factor in asthma, and asthma is associated with impaired lung function. The independent association between sensitization and lung function is unclear. Objectives To examine factors associated with lung function in adolescence, with special i...
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Associations of lung function impairment and biological aging with mortality and cardiovascular disease incidence: findings from UK biobank participants
Được phát hành 2025-07-01“…The joint analysis revealed that participants with both impaired lung function and accelerated biological aging had the highest mortality and CVD risks.ConclusionBiological aging partially mediates the associations between lung function impairment and adverse outcomes, exhibiting synergistic interactions with impaired lung function. …”BackgroundLung function impairment, including preserved ratio impaired spirometry (PRISm) and airflow limitation (AL), is associated with increased risks of mortality and cardiovascular disease; however, the underlying biological mechanisms remain poorly understood. This study aimed to investigate t...
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Association between Anthropometry and Spirometry-based Lung Function Measures among Bengali Children and Adolescents of Asian Indian Origin
Được phát hành 2025-07-01Những chủ đề: lấy văn bảnObejective: To examine the association between body size using anthropometric measures and spirometry-based lung function in Asian Indian children aged 10–18 years. Subjects and Methods: The study was conducted on 136 rural children near Barasat (West Bengal), India. Anthropometric measures were rec...
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Shrinking Lung Syndrome as an Early Manifestation of Systemic Lupus Erythematosus: A Case Report With Literature Review
Được phát hành 2025-07-01Những chủ đề: lấy văn bảnABSTRACT Systemic lupus erythematosus (SLE) can involve the respiratory system through various manifestations, including the rare pulmonary complication known as shrinking lung syndrome (SLS). SLS is characterised by progressive dyspnoea, pleuritic chest pain, diaphragmatic elevation, reduced lung v...
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Association between reduced lung function, hydration and nutritional status in patients on hemodialysis: An observational study using bioelectrical impedance vector analysis (BIVA)
Được phát hành 2025-08-01“…Fluid status was a predictor of reduced lung function in patients on HD.…”Summary: Background & aims: This study aimed to determine the lung function and to investigate the association between pulmonary parameters, hydration, and nutritional status – assessed by bioelectrical impedance vector analysis (BIVA) – in patients on HD. Methods: A cross-sectional study,...
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Preclinical characterisation of changes in cardiac function and circulating biomarkers following differential irradiation of thoracic volumes
Được phát hành 2025-06-01“…Understanding the potential interplay between the heart and lungs is important in the context of optimising cardiac dose distributions that may increase lung doses and minimising the impact of lung dose on cardiac function.…”IntroductionThe heart and lungs are critical organs at risk in patients receiving radiotherapy for thoracic tumours. Preclinical studies in rat models have provided evidence indicating consequential effects of lung radiation on the heart through vascular remodelling which leads to pulmonary arterial...
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A decision rule for identifying patients at high risk for impaired lung diffusion capacity after COVID-19
Được phát hành 2024-10-01Những chủ đề: “…impaired lung diffusion capacity…”Aim. To elaborate a decision rule for identifying the main predictors of impaired lung diffusion capacity after COVID-19. Materials and methods. The retrospective study included 341 patients without underlying lung diseases (median age 48 years) who experienced COVID-19 with bilateral pneumonia. The...
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Quiescence modulates age-related changes in the functional capacity of highly proliferative canine lung mesenchymal stromal cell populations.
Được phát hành 2025-01-01“…The functional capacity of highly proliferative cell populations changes with age. …”The functional capacity of highly proliferative cell populations changes with age. Here, we report that the proliferative capacity of canine lung mesenchymal stromal cells (LMSCs) declines with increasing age of the donor. However, other functional changes such as reduced autophagy, reduced migratio...
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In Silico Lung Deposition Profiles of Three Single-Inhaler Triple Therapies in Patients with COPD Using Functional Respiratory Imaging
Được phát hành 2025-06-01“…This study evaluated the total deposition of 3 single-inhaler triple therapies in the large and small airways.Methods: This study assessed lung deposition of different inhalers using in silico functional respiratory imaging from 20 patients with COPD. …”Dave Singh,1 Nicolas Roche,2,3 Libo Wu,4 Hosein Sadafi,5 Jan De Backer,6,7 Navid Monshi Tousi,5 Jonathan Marshall8 1Respiratory Research Group, University of Manchester, Medicines Evaluation Unit, Manchester University National Health Service Foundation Trust, Manchester, UK; 2Department of Respirat...
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SPECTROMETER FOR MEASUREMENT GAMMA-EMITTING NUCLIDES IN THE HUMAN LUNGS. Part 2. MATHEMATICAL SUPPORT OF AT1316A
Được phát hành 2015-03-01lấy văn bảnIn this article is presented the description of the detection unit of the whole body counter AT1316A. Is shown brief description of the mathematical processing methods. Is presented the main advantages of the offered functions.
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Lung CT Image Segmentation Using VGG-16 Network with Image Enhancement Based on Bounded Turning Mittag-Leffler Function
Được phát hành 2024-12-01“…This study proposes a lung CT image segmentation method which includes two steps: (1) a new image enhancement model that uses the bounded turning Mittag-Leffler function to improve the CT images for better segmentation outcomes. (2) a new modified VGG-16 for infection of lung segmentation based on expanding the original VGG-16 network. …”Automated segmentation of diseases considered a necessary initial step in routine diagnosis. Lung diseases that affect the lungs, such as pneumonia or lung collapse can result in areas of consolidation or atelectasis, where lung tissue becomes denser or collapses. It can be challenging to accuratel...
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Effect of NaCl/Hydroxyethyl Starch 200/0.5 on Lung Function and Hemodynamics in Patients Operated on under Extracorporeal Circulation
Được phát hành 2012-10-01“…Key words: 7.2% NaCl/hydroxyethyl starch 200/0.5; extravascular lung water, respiratory function, cardiac index, osmolarity.…”Objective: to study the effect of 7.2% NaCl/hydroxyethyl starch 200/0.5 on extravascular lung water and respiratory and cardiovascular systems in patients with coronary heart disease (CHD) after myocardial revascularization under extracorporeal circulation (EC). Subjects and methods. A prospective,...
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Real-World Effectiveness of Triple Extrafine Fixed-Dose Combination with Beclomethasone/Formoterol/Glycopyrronium on Symptoms and Lung Function in COPD: A Systematic Review and Meta-Analysis
Được phát hành 2025-05-01Những chủ đề: lấy văn bảnPaola Rogliani,1 Gian Marco Manzetti,1 Mario Cazzola,1 Luigino Calzetta2 1Unit of Respiratory Medicine, Department of Experimental Medicine, University of Rome “Tor Vergata”, Rome, Italy; 2Respiratory Disease and Lung Function Unit, Department of Medicine and Surgery, University of Parma, Parma, Ita...
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