Search Results - Compuscript Ltd

Asymmetric cell division (ACD) has a crucial role in normal cellular differentiation and tissue homeostasis. The mechanisms underlying ACD are highly intricate and involve coordinated molecular and cellular processes. Dysregulation of ACD has been implicated in various human cancers by contributing...

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This study was aimed at screening differentially expressed genes (DEGs) and exploring the potential immune mechanism induced by the Bacillus Calmette-Guerin (BCG) vaccine in a humanized mouse model. Candidate DEGs between mice vaccinated with BCG or injected with PBS were identified through transcri...

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Microorganisms are mostly distributed on the surface of our skin and intestines and have crucial roles in physiologic and metabolic processes, such as digestion and immunity, which are closely related to diseases. Recently, microorganisms have received great attention and have been applied in variou...

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A preclinical study has developed a precision nano-intervention strategy targeting tumor-associated nerves to destroy nerve-fueled tumor growth in pancreatic cancer. In this strategy, Escherichia coli Nissle 1917-derived outer membrane vesicles (OMVs) are decorated with nerve-binding peptide for t...

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This study was aimed at analyzing the pathogenic characteristics of Bordetella hinzii ( B. hinzii ), and elucidating its antibiotic resistance mechanisms, virulence gene distribution, and vaccine development potential. Genomes of 38 global strains were downloaded from the NCBI database. After qual...

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As a mechanical wave capable of transmitting thermal and mechanical energy, ultrasound has emerged as a pivotal tool in regenerative medicine due to its non-invasive nature. Low-intensity pulsed ultrasound (LIPUS), a mechanoregulatory technique independent of thermal effects, delivers controlled mec...

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Recent groundbreaking advances in the structural biology of the glucose transporter 9 (GLUT9) and urate transporter 1 (URAT1) have provided critical insights into the molecular mechanisms underlying urate recognition and transport. Using cryo-electron microscopy (cryo-EM), researchers have elucidate...

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Isosteviol and its derivatives, diterpene compounds with a wide range of biological activities, play important antiviral, antibacterial, antioxidant, antitumor, analgesic, anti-inflammatory, antipyretic, antifungal, and anticardiovascular disease roles. Because of its unique diterpene skeleton, isos...

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Oral fluid (OF) is a new safe, non-invasive, convenient, and efficient biological sample that can be used for virus nucleic acid and antibody detection. Because few studies have performed surveillance of multiple respiratory pathogens, this study sought to explore the application value of OF in this...

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Distribution of the bacterium flora in ticks has an essential role in mapping and preventing local tick-borne diseases. The purpose of the current study was to map the bacterium flora and identify the main pathogens in ticks in grazing areas of Yunnan province. The V3-V4 region of 16S rRNA amplifier...

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Diabetic kidney disease (DKD) is one of the leading causes of end-stage renal disease. Verbascoside is a ubiquitous phenylethanoid glycoside with potent anti-inflammatory, antioxidant, and hypoglycemic properties. This study determined the renoprotective effect of verbascoside against DKD, as well a...

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Psoriasis is a chronic inflammatory disorder for which phosphodiesterase-4 (PDE4) inhibitors have emerged as promising therapeutic agents due to an ability to regulate inflammatory signaling pathways. In this study 1200 methanolic extracts from Chinese medicinal plants were screened and Eclipta pro...

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Kawasaki disease (KD) is a form of vasculitis that affects primarily children and can lead to severe cardiovascular complications. Because current treatment options are often ineffective for some patients, new therapeutic strategies are needed. Cryptotanshinone (CTS), a compound derived from Salvia...

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Previous epidemiologic studies have shown a close association between type 1 diabetes mellitus (T1DM), hyperlipidemia, and inflammatory bowel disease (IBD), but the causal relationship has not been established. In the current study the causal relationships between T1DM and hyperlipidemia with IBD we...

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Bioresponsive materials have gained prominence as innovative tools for advancing drug delivery systems, particularly in managing type 1 and type 2 diabetes mellitus. These materials respond to biological stimuli such as pH, glucose, enzymes, or temperature, thereby enabling spatiotemporally controll...

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Visceral leishmaniasis (VL) is a vector-borne disease posing increasing public health concerns. Although efforts to eliminate VL are underway, its global risk distribution remains unclear, because of changes in transmission risk. Worldwide province-level data on VL incidence were obtained from multi...

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Sodium-glucose cotransporter 2 inhibitors are a class of glucose-lowering drugs known for robust cardiovascular protective properties. However, the side effects induced by Sodium-glucose cotransporter 2 inhibition limit application in cardiovascular medicine. Our prior research showed that thoughtfu...

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