檢索結果 - Brain and Behavior
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Behavioral and Electrophysiological Characterization of Induced Neural Plasticity in the Autistic Brain
出版 2011獲取全文None
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TAAR8 in the Brain: Implications for Dopaminergic Function, Neurogenesis, and Behavior
出版 2025-06-01“...<b>Results:</b> During the study, we found a number of alterations specific to tTAAR8-KO mice compared to controls. tTAAR8-KO mice demonstrated better short-term memory, more depressive-like behavior, and higher body temperature. Also, we observed changes in the dopaminergic system, brain electrophysiological activity, and adult neurogenic functions in mice lacking <i>Taar8</i> isoforms. ...”<b>Background/Objectives:</b> G protein-coupled trace amine-associated receptors (TAARs) belong to a family of biogenic amine-sensing receptors. TAAR1 is the best-investigated receptor of this family, and TAAR1 agonists are already being tested in clinical studies for the treatment of sc...
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Epigenetics of suicidal behavior
出版 2019-08-01“...To solve this problem and interpret the missing relationship between the environment and the genome, promising results were obtained from a study of epigenetic factors, which affected the expression of a number of candidate genes involved in brain functioning in suicidal behavior. The analysis of a brain obtained from suicide victims, representing a unique tool for the analysis of modified genomic processes, revealed a wide range of reprogramming patterns of DNA methylation in promoters of the genes of polyamine (OAZ1, OAZ2, AMD1, ARG2, SKA2), serotonergic (SLC6A4) and GABAergic (GABRA1) systems, HPA-axis (GR, NR3C1), tyrosine kinase (TrkB) receptors, brain-derived neurotrophic factor (BDNF). ...”Suicide is the second leading cause of death among young people and therefore being a serious global problem worldwide. The study of genetic and epigenetic factors in the development of suicidal behavior plays an important role in the development of advanced methods of diagnosis and treatment of thi...
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Does schistosome infection affect behavior through the gut-brain axis?
出版 2025-06-01“...Helminth infections typically establish in early childhood and persist through critical periods of growth and development, leading to cognitive deficits and/or behavioral changes. These deficits could result from the helminths themselves or due to dysbiosis of the gut microbiota and its influence on the gut-brain axis. ...”Parasitic helminths infect over 2 billion people, primarily those living in poverty. Helminth infections typically establish in early childhood and persist through critical periods of growth and development, leading to cognitive deficits and/or behavioral changes. These deficits could result from th...
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PROGRAMMING GENES IN BRAIN AND PROBLEM OF SOCIAL BEHAVIOR ОF MAN
出版 2013-04-01“...Transcription factors programmed genes of brain cells. Then proteins synthesized form long term memory. ...”Transcription factors programmed genes of brain cells. Then proteins synthesized form long term memory. Two genes of hormone vasopressin receptor – genes of altruism / selfishnessand one oxytocin receptor gene provide social recognition, memory and behavior. Human population divided into three group...
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Early-Life Mild Traumatic Brain Injury Alters Neurodevelopment and Behavior in Mice
出版 2025-01-01主題: “...behavior...”Approximately 280 children per 100,000 experience closed-head injuries each year, with over 80% being mild in severity. While most children with mild injuries do not require admission to a hospital and recover well over time, some children experience persistent behavioral and cognitive abnormalities...
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Sedentary behavior, cognition, and brain health in older adults: a systematic review
出版 2025-07-01主題: “...sedentary behavior...”Sedentary behavior has been associated with poor health outcomes, especially in older adulthood. Given that sedentary behavior is a highly prevalent, modifiable health behavior, there has been a recent increased interest in examining how sedentary behavior relates to cognition and brain health. The...
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Associations of serotonin-related brain morphology in early adolescence with behavioral and emotional problems
出版 2025-01-01“...We aimed to investigate the association of brain morphology with behavioral and emotional problems in early adolescence using a brain atlas of the serotonin system. ...”We aimed to investigate the association of brain morphology with behavioral and emotional problems in early adolescence using a brain atlas of the serotonin system. This pre-registered study used data from the Generation R Study, a large birth cohort in Rotterdam, the Netherlands. A total of 2492 ch...
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ADHD and Stress: The Role of Meditation to Reduce Stress, and Improve Brain Function and Behavior Regulation
出版 2012獲取全文None
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EEG Response to Sedation Interruption Complements Behavioral Assessment After Severe Brain Injury
出版 2025-07-01“...This study assesses the brain's electroencephalogram response during an interruption of propofol sedation to complement behavioral assessment during the neurological wake‐up test to predict survival, recovery of consciousness, and long‐term functional outcomes in patients with acute severe brain injury. ...”ABSTRACT Objective Accurate assessment of the level of consciousness and potential to recover in patients with severe brain injury underpins crucial decisions in the intensive care unit but remains a major challenge for the clinical team. The neurological wake‐up test is a widely used assessment too...
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Neuroimaging and Emotional Development in the Pediatric Population: Understanding the Link Between the Brain, Emotions, and Behavior
出版 2025-06-01“...Neuroimaging has emerged as an innovative and essential tool for understanding the intricate relationship between brain development, emotions, and behavior. Investigating the neurobiological mechanisms underlying this interaction during the critical phase of brain maturation is crucial for promoting individual psychological well-being and mitigating the profound impact of mood disorders during childhood. ...”Neuroimaging has emerged as an innovative and essential tool for understanding the intricate relationship between brain development, emotions, and behavior. Investigating the neurobiological mechanisms underlying this interaction during the critical phase of brain maturation is crucial for promoting...
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Expression of palmitoyl transferases in brain structures of mice genetically predisposed to depressive-like behavior
出版 2018-08-01“...However, no association between palmitoyl transferases and depressive-like behavior has been found hitherto. There is no information on brain structure specific features of palmitoyl transferase expression either. ...”Most G-coupled receptors undergo posttranslational modifications. Among these modifications is S-palmitoylation, carried out by specialized enzymes palmitoyl transferases. Palmitoylation is the covalent attachment of a long-chain fatty acid, palmitate, to cysteine residues. It can influence receptor...
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Linking intrinsic brain dysfunction to behavioral outcomes in combat-exposed males with PTSD symptoms
出版 2025-07-01“...Importantly, regional abnormalities were detrimental for more complex executive functions, consistent with observations that stress impedes cognitive flexibility and inhibitory control due to a persistent reliance on hypervigilant behaviors.DiscussionAn unbiased, efficient and computationally reliable imaging approach identified intrinsic dysfunction in brain regions that may be core features of CE-PTSD. ...”IntroductionExposure to trauma produces abnormal intrinsic brain activity, but its association to stress-related symptom severity is often elusive, and the relationships with co-occurring psychiatric and cognitive changes are poorly understood.MethodsThis study investigated the neurobehavioral mecha...
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AGGRESSIVE BEHAVIOR CORRECTION BY THE TRANSPLANTATION OF IN VITRO MODULATED IMMUNE CELLS
出版 2021-10-01主題: “...aggressive behavior...”Aggression is a serious biomedical problem associated with a high percentage of patients and a lack of selective corrective agents. The most frequent increase in aggressiveness occurs in patients with depressive disorders, schizophrenia, reactive psychoses and adjustment disorders, which are known t...
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Computational phenotyping of brain-behavior dynamics underlying approach-avoidance conflict in major depressive disorder.
出版 2021-05-01獲取全文Adaptive behavior requires balancing approach and avoidance based on the rewarding and aversive consequences of actions. Imbalances in this evaluation are thought to characterize mood disorders such as major depressive disorder (MDD). We present a novel application of the drift diffusion model (DDM)...
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Altered Brain‐Behavior Association During Resting State is a Potential Psychosis Risk Marker
出版 2025-07-01主題: 獲取全文Abstract Alterations in cognitive and neuroimaging measures in psychosis may reflect altered brain‐behavior interactions patterns accompanying the symptomatic manifestation of the disease. Using graph connectivity‐based approaches, we tested the brain‐behavior association between cognitive functioni...
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