Search Results - BMC

Abstract The advent of the omics era has facilitated the identification of precise biomarkers for cancer progression, revealing a broader diversity of macrophage phenotypes beyond the traditional M1/M2 classification. Folate receptor 2 (FOLR2)-positive macrophages, co-expressing markers such as mann...

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Abstract Machine learning methods, especially Transformer architectures, have been widely employed in single-cell omics studies. However, interpretability and accurate representation of out-of-distribution (OOD) cells remains challenging. Inspired by the global workspace theory in cognitive neurosci...

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Abstract Background Sugarcane bagasse is an organic waste material abundant in silica. Silica is a very significant inorganic substance that is widely employed in a variety of industrial applications.This study displays an eco-friendly and inexpensive biotransformation process producing silica nanop...

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Abstract Purpose Convalescent plasma (CP), obtained from individuals who have recovered from COVID-19, has been widely explored as a potential therapeutic option, particularly in the absence of vaccines and monoclonal antibody treatments. This study aimed to evaluate the effectiveness of CP therapy...

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Abstract Background Despite increasing in vitro research, direct evidence of how abnormal α-synuclein (α-Syn) dysregulates vesicular transport and synaptic function in the human brain is lacking. Methods We performed a transcriptome analysis using brain tissues from a multiple system atrophy (MSA) m...

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Abstract Background Serological assays for hepatitis A virus (HAV) play a crucial role in diagnosing acute infections and monitoring disease transmission. Given their widespread use in clinical laboratories, discrepancies among different immunoassay analyzers may have significant clinical implicatio...

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Abstract Background Sustained HIV care engagement is essential for pregnant women living with HIV (PWLHIV) on lifelong antiretroviral therapy (ART). However, transferring clinics, missed HIV visits, and disengagement from HIV care can make monitoring engagement challenging. This study evaluated the...

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Abstract Background Peptic ulcer perforation (PUP) is a surgical emergency and life-threatening complication affecting 2–10% of peptic ulcer disease (PUD) patients. Delayed diagnosis and surgical management are associated with significant morbidity and mortality. This study assessed the magnitude an...

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Abstract Background Whether elevated homocysteine level is causally associated with small bowel necrosis remains unestablished. We conducted a prospective observational study to analyze the value of serum homocysteine (HCY) in predicting irreversible transmural intestinal necrosis (ITIN) of adhesive...

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Abstract Purpose To determine the risk factors for complications after hip or knee replacement surgery in elderly patients. Methods In total, 401 elderly patients (aged ≥ 65 years) who underwent hip or knee replacement surgery at a hospital from January 2017 to December 2022 were retrospectively ana...

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Abstract Background Patients with end-stage kidney disease suffer from uncertainty in illness and low activation. Individualized education is a new approach in which education is provided on the basis of the patient’s needs and preferences. This study aims to assess the influence of nurse-led indivi...

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Abstract Konjac mannan oligosaccharides (KMOS) are currently popular in food additives for their health benefits. However, the simple and efficient preparation of KMOS is still a challenge. In this study, A novel gene encoding β-mannanase (CsMan134) from Cellvibrio sp. KY-GH-1 was displayed on the s...

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Abstract Glaucoma is characterized by progressive retinal ganglion cell (RGC) loss and optic nerve head (ONH) changes, but the roles of glial activation and immune responses remain unclear. This study examines gliosis, microglial diversity, and inflammation in postmortem retinal tissues. Postmortem...

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Abstract Background Acute stroke care has evolved markedly in recent decades, yet long-term trends across stroke subtypes remain understudied. This study analyzed national trends in inpatient stroke care for ischemic stroke (IS), intracerebral hemorrhage (ICH), and subarachnoid hemorrhage (SAH) in G...

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Abstract Despite groundbreaking advances in cancer immunotherapy, clinical efficacy remains constrained by the immunosuppressive tumor microenvironment (TME). As key stromal components within this TME, cancer-associated fibroblasts (CAFs) emerge as pivotal regulators of drug resistance and immune ev...

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Abstract Background Podocyte dysfunction is central to various glomerular diseases, necessitating reliable biomarkers for early detection and diagnosis. This study investigates the regulatory mechanisms of membrane-associated guanylate kinase inverted 2 (MAGI2) and its potential as a biomarker for p...

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Abstract Advances in spatial transcriptomics demand new tools to integrate data across tissue slices and identify consistent spatial domains. We introduce spCLUE, a comprehensive framework combining multi-view graph network, contrastive learning, attention mechanisms, and a batch prompting module to...

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Abstract Background Experimental data from functional assays have a critical role in interpreting the impact of genetic variants. Assay data must be unambiguously mapped to a reference genome to make it accessible, but it is often reported relative to assay-specific sequences, complicating downstrea...

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Abstract Objectives This article aimed to investigate the virulence gene profile of Helicobacter pylori (H. pylori) clinical isolates and explore potential correlations between virulence genes and antimicrobial resistance. Methods Fifty-six H. pylori strains isolated from gastric biopsy specimens we...

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