Search Results - "white matter"

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  1. 1
    Association between white matter hyperintensities and gray matter volume in cerebral small vessel disease: insights from periventricular and deep white matter lesions

    Association between white matter hyperintensities and gray matter volume in cerebral small vessel disease: insights from periventricular and deep white matter lesions by Weishun Feng, Xinjun Lei, Shida Xu, Zhihua Xu

    Published 2025-07-01

    ObjectiveTo investigate the relationship between the severity of periventricular white matter hyperintensities (PWMH) and deep white matter hyperintensities (DWMH) and gray matter volume in cerebral small vessel disease (CSVD) patients.MethodsClinical and imaging data from 125 CSVD patients, collect...

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  2. 2
    Associations of Handgrip Strength and Testosterone With Cerebral White Matter Hyperintensity and Microstructural Injury

    Associations of Handgrip Strength and Testosterone With Cerebral White Matter Hyperintensity and Microstructural Injury by Yuna Li, Shan Tian, Yuan Qiao, Chaohua Cong, Junting Yang, Shanshan Cao, Xirui Zhu, Lei Zhao, Panlong Li, Jingjing Su

    Published 2025-06-01

    ABSTRACT Background White matter hyperintensity (WMH) is one of the key imaging markers of cerebral small vessel disease (CSVD) and white matter microstructural injury may occur earlier than WMH. However, the associations of handgrip strength (HGS) and serum total testosterone (STT) with WMH and mic...

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  3. 3
    Vascular risk factors and neuroimaging heterogeneity across different white matter hyperintensities distribution patterns

    Vascular risk factors and neuroimaging heterogeneity across different white matter hyperintensities distribution patterns by Junjun Wang, Liying Zhuang, Fengli Fu, Yejia Mo, Lihao Zhai, Qi Xu, Caiyun Mou

    Published 2025-07-01

    BackgroundDifferent white matter hyperintensities (WMHs) distribution patterns exhibit distinct clinical implications, but their underlying mechanisms remain unclear. This study explores vascular risk factors and neuroimaging features to elucidate their heterogeneity.MethodsWe retrospectively analyz...

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  4. 4
    Association between serum uric acid levels and white matter hyperintensities in patients with mild ischemic stroke

    Association between serum uric acid levels and white matter hyperintensities in patients with mild ischemic stroke by Chaoxin Chai, Chaoxin Chai, Chaoxin Chai, Yuqi Cui, Yuqi Cui, Yuqi Cui, Meng Li, Meng Li, Meng Li, Jianing Xia, Jianing Xia, Jianing Xia, Yiming Wang, Yiming Wang, Yiming Wang, Fuyun Ren, Fuyun Ren, Fuyun Ren, Liping Chen, Liping Chen, Liping Chen

    Published 2025-07-01

    ObjectiveThis study aims to investigate the association between uric acid (SUA) level and white matter hyperintensities (WMH) in patients with mild ischemic stroke.Methods and resultsThis study retrospectively analyzed 290 patients with mild ischemic Stroke who were hospitalized at the Second Hospit...

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  5. 5
    Increased white matter hyperintensities on MRI in autosomal dominant familial compared to sporadic Alzheimer’s disease

    Increased white matter hyperintensities on MRI in autosomal dominant familial compared to sporadic Alzheimer’s disease by Alice Accorroni, Maggie R Fraser, Phoebe Walsh, Antoinette O’Connor, M Jorge Cardoso, Llwyd Prosser, Nick C Fox, Carole H Sudre, Natalie S Ryan

    Published 2025-09-01

    Background: White matter hyperintensities (WMH) on MRI may be observed in autosomal dominant familial Alzheimer’s disease (FAD) and sporadic AD (SAD), however, studies comparing WMH burden between these two groups are lacking. Methods: In this cross-sectional study, we evaluated global and local dif...

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  6. 6
    Combined Functional and Structural Imaging of White Matter Reveals Brain Connectivity Alterations in Fibromyalgia Patients

    Combined Functional and Structural Imaging of White Matter Reveals Brain Connectivity Alterations in Fibromyalgia Patients by Gao Z, Xie X, Liu F, Xu T, Zhang N, Zhang X, Li Y, Kong Y, Lv D, Wu T

    Published 2025-07-01

    Ziyi Gao,1 Xinyan Xie,1 Fuyuan Liu,2 Tong Xu,1 Nan Zhang,1 Xinran Zhang,1 Yun Li,1 Youyong Kong,2 Dongling Lv,3 Ting Wu1 1Department of Radiology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, People’s Republic of China; 2Jiangsu Provincial Joint Inter-School of Computer Sc...

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  7. 7
    Comparison of Acoustocerebrography Measurement and Magnetic Resonance Imaging Methods in the Assessment of White Matter Lesions in Patients with Atrial Fibrillation

    Comparison of Acoustocerebrography Measurement and Magnetic Resonance Imaging Methods in the Assessment of White Matter Lesions in Patients with Atrial Fibrillation by Wioletta DOBKOWSKA-CHUDON, Mirosław WROBEL, Emilia FRANKOWSKA, Arkadiusz ZEGADLO, Andrzej KRUPIENICZ, Andrzej NOWICKI, Robert OLSZEWSKI

    Published 2020-07-01

    The brain is subject to damage, due to ageing, physiological processes and/or disease. Some of the damage is acute in nature, such as strokes; some is more subtle, like white matter lesions. White matter lesions or hyperintensities (WMH) can be one of the first signs of micro brain damage. We implem...

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  8. 8
    Associations of history of traumatic brain injury with markers of brain health among older men in the Vietnam Era Twin Study of Aging

    Associations of history of traumatic brain injury with markers of brain health among older men in the Vietnam Era Twin Study of Aging by Alexander Ivan B. Posis, Jeremy A. Elman, John E. Alcaraz, Humberto Parada, Jr., Aladdin H. Shadyab, Christine Fennema-Notestine, Donald J. Hagler, Jr., Michael J. Lyons, Matthew S. Panizzon, Chandra A. Reynolds, Carol E. Franz, William S. Kremen, Linda K. McEvoy

    Published 2025-01-01

    Background: Traumatic brain injury (TBI) is associated with increased risk of dementia, but it is unclear how earlier life TBI is related to brain health in older age. Methods: This cross-sectional study compared 517 male Vietnam Era Twin Study of Aging participants with and without a history of TBI...

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  9. 9
    X-ray interaction and computational characterization and analysis of human brain tissue for applications in cancer detection

    X-ray interaction and computational characterization and analysis of human brain tissue for applications in cancer detection by Aysun Böke

    Published 2025-10-01

    This study covers the 1–140 keV energy region, which includes the photoelectric effect, coherent (Rayleigh) and incoherent (Compton) scattering. The study was conducted by testing the different elemental contents from the literature regarding the molecular structure of the human brain grey and white...

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  10. 10
    Cerebrospinal fluid YKL‐40 relates to white matter hyperintensity progression in females but not males over a 6‐year period

    Cerebrospinal fluid YKL‐40 relates to white matter hyperintensity progression in females but not males over a 6‐year period by Amalia J. Peterson, Yunyi Sun, Derek B. Archer, Hailey A. Adegboye, Elizabeth E. Moore, Isabella Deberghes, Kimberly R. Pechman, Niranjana Shashikumar, W. Hudson Robb, Abigail W. Workmeister, T. Bryan Jackson, Dandan Liu, Logan Dumitrescu, L. Taylor Davis, Bennett A. Landman, Kaj Blennow, Henrik Zetterberg, Timothy J. Hohman, Angela L. Jefferson

    Published 2025-04-01

    Abstract INTRODUCTION Neuroinflammation may have sex‐specific effects on white matter injury and impact the development of dementia. METHODS Human chitinase‐3‐like protein‐1 (YKL‐40) concentrations at baseline were related to white matter hyperintensity (WMH) volume, free water (FW), and FW‐correcte...

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  11. 11
    Effects of agricultural or gardening physical activity on cardiovascular disease and dementia-related markers via arterial stiffness, cognitive function, and cerebral white matter status: results from cross-sectional and interventional studies

    Effects of agricultural or gardening physical activity on cardiovascular disease and dementia-related markers via arterial stiffness, cognitive function, and cerebral white matter... by Masato Nishiwaki, Seiya Takada, Seiya Takada, Shotaro Otsuka, Hyuma Makizako, Harutoshi Sakakima, Naoto Shiomi, Satomi Ooba, Naoyuki Matsumoto, Kiyoshi Kikuchi, Kiyoshi Kikuchi

    Published 2025-07-01

    BackgroundAgricultural or gardening physical activity (AGPA) offers potential as a simple strategy to improve cardiovascular disease and dementia-related markers; however, the actual preventive effects remain unclear. Our objective was to investigate AGPA regarding related markers of cardiovascular...

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  12. 12
    Development and validation of a conventional MRI-based model to predict cerebral palsy in infants (aged 6–24 months) with periventricular white matter injury: a multicentre, retrospective cohort studyResearch in context

    Development and validation of a conventional MRI-based model to predict cerebral palsy in infants (aged 6–24 months) with periventricular white matter injury: a multicentre, retros... by Tingting Huang, Jie Zheng, Heng Liu, Haoxiang Jiang, Chao Jin, Xianjun Li, Liang Wu, Lei Zhang, Congcong Liu, Yitong Bian, Miaomiao Wang, Fan Wu, Xin Zhao, Shengli Shi, Fei Wang, Mengxuan Li, Linlin Zhu, Yuying Feng, Gang Zhang, Jian Yang

    Published 2025-08-01

    Summary: Background: Periventricular white matter injury (PVWMI) is the most common form of brain injury and the leading cause of cerebral palsy (CP). Early prediction of CP within the first 2 years of life is crucial for timely and effective intervention. Early CP prediction tools for infants with...

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  13. 13
    White Matter Hyperintensities Mediate the Negative Impact of HbA1c Levels on Cognitive Function

    White Matter Hyperintensities Mediate the Negative Impact of HbA1c Levels on Cognitive Function by Rudolph Johnstone, Ida Rangus, Natalie Busby, Janina Wilmskoetter, Nicholas Riccardi, Sarah Newman-Norlund, Roger Newman-Norlund, Chris Rorden, Julius Fridriksson, Leonardo Bonilha

    Published 2025-06-01

    Background: Type 2 diabetes is linked to impaired cognitive function, but the underlying mechanisms remain poorly understood. As white matter hyperintensities (WMHs) are common in diabetes and associated with vascular brain injury, we investigated whether WMH burden mediates the relationship between...

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  14. 14
    An observational study on gray matter volume and white matter integrity in suicide attempters with bipolar I disorder

    An observational study on gray matter volume and white matter integrity in suicide attempters with bipolar I disorder by Anuranjan Vishwakarma, Pankaj, Raman Deep, S Senthil Kumaran, Pratap Sharan

    Published 2025-06-01

    Background: Bipolar disorder (BD) is associated with a high risk of lifetime suicide attempts, but relatively few neuroimaging studies have investigated suicidality in the context of BD. Aim: The study aimed to assess the white matter (WM) integrity and gray matter (GM) volume associated with suicid...

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  15. 15
    Mastication Influences Human Brain Anatomy

    Mastication Influences Human Brain Anatomy by Lucia Lopez-Chaichio, Pablo Galindo-Moreno, Miguel Padial-Molina, Lourdes Gutierrez-Garrido, Roque Rodriguez-Alvarez, Francisco O’Valle, Andres Catena

    Published 2024-12-01

    Objectives: The purpose of this observational clinical study was to evaluate the relationship between brain anatomical and volumetric changes in white matter, grey matter, and cerebral cortex thickness with the number of functional occlusal pairs present in the mouth. Material and Methods: The nu...

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  16. 16
    Choroidal Vascular Volume, White Matter Hyperintensity, and Their Interaction With Cognitive Function in Aging Adults

    Choroidal Vascular Volume, White Matter Hyperintensity, and Their Interaction With Cognitive Function in Aging Adults by Youjie Wang, Ruilin Wang, Hang Wang, Le Cao, Chen Ye, Junfeng Liu, Bo Wu, William Robert Kwapong, Wendan Tao

    Published 2025-06-01

    Background Reports have proposed the retinal choroid as a potential biomarker for dementia and cerebral age‐related disorders. However, the clinical use of the choroid as a surrogate marker remains underexplored. This study investigated the associations among choroidal perfusion, white matter hyperi...

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  17. 17
    Imaging‐Based Brain Frailty Predicts Unfavorable Outcomes in Acute Ischemic Stroke

    Imaging‐Based Brain Frailty Predicts Unfavorable Outcomes in Acute Ischemic Stroke by XiaoQing Cheng, Wu Cai, ChuYan Li, Xi Shen, JiaNan Li, LiJun Huang, JinJing Tang, HuiMin Pang, BaiYan Luo, Ya Liu, Qian Chen, Lulu Xiao, WuSheng Zhu, ZeHong Cao, XiaoYu Liu, LongJiang Zhang, XinDao Yin, ZhiQiang Zhang, Feng Shi, Wei Xing, GuangMing Lu

    Published 2025-06-01

    Background Brain frailty is characterized by imaging biomarkers of chronic cerebrovascular injury. Whether brain frailty improves the prediction of acute ischemic stroke complications and prognosis requires further study. Methods This multicenter, retrospective study included patients with acute isc...

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  18. 18
    DTI Histogram and Texture Features as Early Predictors of Post-Radiotherapy Cognitive Decline

    DTI Histogram and Texture Features as Early Predictors of Post-Radiotherapy Cognitive Decline by Jincheng Wang, Philip Kyeremeh Jnr Oppong, Maho Kitagawa, Hidefumi Aoyama, Shunsuke Onodera, Satoshi Terae, Khin Khin Tha

    Published 2025-06-01

    <b>Background:</b> Radiotherapy for brain tumors can induce cognitive decline, yet most studies examine white matter (WM) damage six months post-treatment, overlooking early microstructural changes. This study investigated whether early WM changes, as measured by diffusion tensor imaging...

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  19. 19
    Association between periventricular hyperintensity or deep white matter hyperintensity and outcomes of patients with ischemic stroke

    Association between periventricular hyperintensity or deep white matter hyperintensity and outcomes of patients with ischemic stroke by Hongwei Ren, Du Wang, Xing Wang, Jinlong Wu, Junli Huang, Honghua Jin, Chengfang Huang, Lei Lei

    Published 2025-06-01

    IntroductionThis study investigates the association between white matter hyperintensities (WMH), specifically periventricular hyperintensity (PVH) and deep white matter hyperintensity (DWMH), and the prognosis and recurrence risk in patients with ischemic stroke.MethodsA retrospective analysis was c...

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  20. 20
    Phase contrast-derived cerebral blood flow is associated with neurodegeneration and cerebrovascular injury in older adults

    Phase contrast-derived cerebral blood flow is associated with neurodegeneration and cerebrovascular injury in older adults by Jeffrey D. Pyne, Jeffrey D. Pyne, Jeffrey D. Pyne, Clarissa D. Morales, Clarissa D. Morales, Clarissa D. Morales, A. Zarina Kraal, A. Zarina Kraal, A. Zarina Kraal, Mohamad J. Alshikho, Mohamad J. Alshikho, Mohamad J. Alshikho, Patrick J. Lao, Patrick J. Lao, Patrick J. Lao, Indira C. Turney, Indira C. Turney, Indira C. Turney, Erica Amarante, Erica Amarante, Erica Amarante, Rafael V. Lippert, Rafael V. Lippert, Rafael V. Lippert, Julia F. Chang, Julia F. Chang, Julia F. Chang, Jose Gutierrez, Jose Gutierrez, Jose Gutierrez, Jennifer J. Manly, Jennifer J. Manly, Jennifer J. Manly, Richard Mayeux, Richard Mayeux, Richard Mayeux, Richard Mayeux, Adam M. Brickman, Adam M. Brickman, Adam M. Brickman

    Published 2025-07-01

    Global cerebral blood flow and the local delivery of blood through the vascular network are essential to maintain brain and cognitive health throughout the lifespan. In this cross-sectional study, we examined the association of extracranial blood flow into the brain, measured with phase contrast mag...

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