Search Results - "ursodeoxycholic acid"

Background: Infantile jaundice affects up to 84% of term infants and is a primary cause of re-hospitalization. Phototherapy, the primary therapeutic intervention, may be associated with several complications. Therefore, employing additional compensatory therapies could reduce the duration of phototh...

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Patients with chronic virus hepatitis (32 patients, 13 with chronic hepatitis B and 19 with chronic hepatitis C) ages from 20 to 72 with elevated levels of bilirubin and active alanine aminotransferase, aspartate aminotransferase, gamma- glutamyl transpeptidase, received ursodeoxycholic acid (Urdoxa...

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Ursodeoxycholic acid (UDCA) is a hydrophilic bile acid, a potent antioxidant, which is currently used as a «panacea» for drug treatment of wide range of hepatic diseases. Pharmacokinetics and action mechanisms of UDCA were shown, as well as UDCA use in different cholestatic diseases. UDCA is widely...

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The aim of review. To describe prevalence, basic mechanisms, risk factors and variants of course of biliary sludge, and methods of its treatment.Original positions. Biliary sludge consists of inhomogeneous structures, suspension and clots in bile. Its prevalence in general population ranges 1,7 to 4...

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The aim of review. To cite the literature data, confirming efficacy of ursodeoxycholic acid (UDCA) at alcoholic and non-alcoholic steatohepatitis (NASH).Original positions. Prevalence of liver steatosis as pathomorphologic substrate of various liver diseases is quite high, however the special attent...

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We conducted a study to assess the bile lithogenicity in patients with type 2 diabetes mellitus (DM). We have found increased levels of cholesterol both in the gallbladder and hepatic bile. The study showed a decrease of cholatocholesterol coefficient (HHC), increase of lithogenic index Thomas–Hofma...

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242 patients with increase of body mass index were examined, of them, in 180 patients, fatty hepatosis was revealed. In the course of the examination, we defined manifestations of metabolic disorders in the patients: obesity, disorders in glucose tolerance, dislipidemy, arterial hypertension. In the...

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The aim of presentation of clinical case – to show endoscopically and histologically proved Barret’s esophagus, at the patient after gastrectomy without previous history of gastroesophageal reflux disease.Features of clinical case. The male patient, 59 years old, 7 years ago underwent gastrectomy fo...

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Aim of the Study. The administration of ursodeoxycholic acid (UDCA) as monotherapy or in combination with lactulose for the treatment of the patients with nonalcoholic steatohepatitis (NASH) has been studied insufficiently. The aim was to assess the impact of the 90-day therapy with Ursoliv® drug (2...

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Purpose: To prove the efficacy of Ursodeoxycholic acid Urdoksa as hepatoprotector in patients with cardiac fibrosis of the liver.Materials and Methods: We examined 30 patients before and after a month’s course of therapy with 500 mg per day.Results: All patients had statistically significant positiv...

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Background. Recent studies and guidelines recognize non-alcoholic fatty liver disease (NAFLD) as an interdisciplinary problem at the intersection of gastroenterology, cardiology and endocrinology. The increased interest in NAFLD in recent years, as the most common chronic disease, identifies this pa...

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Primary sclerosing cholangitis (PSC) is autoimmune disease characterized by inflammation and sclerosis of the bile duct, which leads to the development of secondary biliary cirrhosis. Many women with primary sclerosing cholangitis are at reproductive age (mean age of onset is 40 years old, but the c...

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The aim of review. To present data on pathogenic significance of bile acids for upper regions of gastrointestinal tract (GIT) and to describe medical properties ursodeoxycholic acid (UDCA) at reflux-gastritis.Summary. Reflux-gastritis is chemical type gastritis, morphologically manifested by foveola...

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In a retrospective study the efficacy and safety of using ursodeoxycholic acid 10 mg / kg for 12 months in 76 patients with biliary sludge was assessed. Biliary pain was relieved in 64 (84.2%). Dissolution of biliary sludge occurred in 61 (80.3%) patients. The choice of the reference ursodeoxycholic...

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The aim of review. To generalize literature and authors own data on clinical and laboratory criteria of primary biliary cirrhosis (PBC) diagnostics and treatment.Original positions. PBC is organ-specific autoimmune liver disease affecting predominantly women that is characterized by chronic progress...

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The article presents results of the study whose objective was efficiency assessment for application of ursodeoxycholic acid in the frameworks of minimization of hepatotoxic action of antibacterial drugs included in the composition of classical triple scheme of eradication therapy of Helicobacter pyl...

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Introduction. For the treatment of non-alcoholic fatty liver disease (NAFLD), hepatoprotective drugs are actively used. The existing models of non-alcoholic fatty liver disease used to study the effectiveness of medicinal products are characterized by a long duration of recovery and high mortality o...

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Aim: Evaluating prognostic scores' utility in predicting ursodeoxycholic acid (UDCA) biochemical response (BR) and long-term liver-related complications in primary biliary cholangitis (PBC) patients. Patients & methods: This retrospective single-center study included 50 predominantly female...

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Background. Non-alcoholic fatty liver disease occupies a leading position among the causes of diffuse liver diseases, both in Russia and in the world, while there is a steady upward trend in the incidence, especially in the cohort of patients with metabolic risk factors. In Russia, over the past 7 y...

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Cardiovascular diseases continue to be the leading cause of death throughout the world and in Russia. Therefore, new possible risk factors for their development and progression are being studied. To date, information have been accumulated on unfavorable prognostic effect of elevated trimethylamine o...

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