Search Results - "targets"

The article describes the psychological characteristics of the personality of patients with multiple sclerosis (MS), which can be identified as the main targets of psychotherapy for comorbid post-traumatic stress disorder (PTSD). A total of 127 patients with MS were examined, of which 61 patients ha...

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Background: Diabetes mellitus is a multifactorial metabolic disorder involving several pathways, i.e., enzymes and proteins, and is a major causing morbidity and mortality worldwide. Its complex nature makes it a target for multiple therapeutic approaches, each addressing specific dysfunctions to a...

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Introduction: Trichuris trichiura, a soil-transmitted helminth, resides in the large intestine of humans, causing an asymptomatic disease known as trichuriasis. This global health concern is particularly prevalent in low- or middle-income countries, representing a significant burden on public healt...

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Radiation-induced vascular damage has attracted significant attention in various fields, including healthcare (radiotherapy), the nuclear industry (nuclear facilities and devices), and space exploration. Recent studies have indicated a close relationship between such damage and aging, involving mult...

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Background. multiple myeloma (mm) is a plasma cell cancer that affects white blood cells. plasma cells from the bone marrow grow abnormally, as a consequence of which patients have high amounts of monoclonal immunoglobulin in their blood and urine, poor renal function, and recurring infections due t...

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Zhonghao Jiang,1,* Baolin Qian,1,* Tongjie Xu,1,2 Junjie Bai,1 Wenguang Fu1,3 1Department of Biliary-Pancreatic Center, The Affiliated Hospital of Southwest Medical University, Luzhou, People’s Republic of China; 2Department of Vascular Surgery, The Affiliated Hospital, South...

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Lung cancer remains one of the leading causes of cancer-related deaths worldwide, highlighting the urgent need for enhanced diagnostic and therapeutic strategies. Mucins, a family of glycoproteins crucial for maintaining epithelial integrity and regulating immune responses, have emerged as promising...

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Pericytes are multi-functional mural cells of the central nervous system that cover the capillary endothelial cells. Pericytes play a vital role in nervous system development, significantly influencing the formation, maturation, and maintenance of the central nervous system. An expanding body of stu...

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Siyu Zhao, Jia Zheng, Songkai Yue, Xiaoyang Chen, Yonghui Dong Department of Orthopedics, Henan Provincial People’s Hospital, People’s Hospital of Zhengzhou University, Zhengzhou, Henan, People’s Republic of ChinaCorrespondence: Yonghui Dong, Department of Orthopedics, Henan Provincial People’s Hosp...

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The association of arterial hypertension and metabolic abnormalities increases the risk of cardiovascular events. It damages more organs. The correlation between the speed of myocardial hypertrophy and degreeses of metabolic abnormalities has been demonstrated in prospective studies. Interventricula...

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Abstract Introduction Human brucellosis is a zoonotic bacterial disease with up to 500,000 new cases each year. The major evasion mechanisms from the host immune system by Brucella are restraint of complement pathway and Toll‐like receptors signaling pathways, interference with efficient antigen pre...

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Systemic Lupus Erythematosus (SLE) is a multifaceted autoimmune disorder characterized by widespread inflammation and immune dysregulation, impacting various organ systems and generating autoantibodies. Oral lesions are a common and distressing manifestation of SLE, significantly affecting patients’...

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Algorithms of video stabilization from unmanned aerial vehicle board and search of small size targets on the video sequence frames with the prediction are proposed. Proposed stabilization method provides a parametrization and localization time reduction to 5.2 times compared with the SURF method. Pr...

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To enhance the signature of an extended target in a SAR image, a robust waveform design method is presented for spectrally dense environments. First, the problem is formulated by maximizing the worst-case signal-to-clutter ratio (SCR) over the uncertainty set of statistics for both target and backgr...

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Polycystic ovary syndrome (PCOS), a common yet intricate endocrine disorder, presents persistent clinical challenges due to its complex pathogenesis. Reactive oxygen species (ROS), highly reactive molecules, have emerged as critical contributors to PCOS development and represent potential therapeuti...

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Arterial hypertension (HT) takes leading position in the structure of morbidity and mortality among the cardiovascular diseases in the economically developed and developing countries of the world. Despite progress in treatment of this disease, a number of people with uncontrolled or resistant HT inc...

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Background Inflammation and immune responses play key roles in osteoporosis (OP) pathogenesis. Osteoimmunology highlights immune dysregulation as a significant contributor to OP, but the specific biological mechanisms linking immune dysfunction to bone loss remain unclear. Understanding these mechan...

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The review considers the current views on pathogenesis and therapeutic targets in infectious diarrhea that develops as a result of exposure of enterocytes to viruses or bacterial toxins. The main methods of infectious diarrhea treatment and disadvantages of standard therapy are described. Modern dat...

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