Search Results - "rosuvastatin"

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  1. 1
    Pharmacokinetic and Bioequivalence Study of the Two-component Drug Product "Ezetimibe + rosuvastatin" (JSC "Sanofi-aventis group", Russia): Resuts and Experience with the Use of Enzymatic Hydrolysis in the Analysis of Samples

    Pharmacokinetic and Bioequivalence Study of the Two-component Drug Product "Ezetimibe + rosuvastatin" (JSC "Sanofi-aventis group", Russia): Resuts and Experience with the Use of En... by A. L. Khokhlov, D. Yu. Grebenkin, E. K. Faeva, V. I. Kazey, A. A. Khokhlov, A. E. Miroshnikov, O. V. Lebedeva

    Published 2023-02-01

    Introduction. As a part of the registration of the drug product a bioequivalence study of the fixed-dose combination "Ezetimibe + rosuvastatin" (JSC "Sanofi-aventis group", Russia) compared with coadministered Ezetrol® (ezetimibe) and Crestor® (rosuvastatin) was conducted with 76...

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  2. 2
    NEW OPPORTUNITIES FOR PREVENTIVE THERAPY WITH STATINS DURING CHD PATIENTS’ REHABILITATION, WITH CLINICAL SIGNS OF MODERATE CHF: EFFECTIVENESS OF ROSUVASTATIN AND EZETIMIBE

    NEW OPPORTUNITIES FOR PREVENTIVE THERAPY WITH STATINS DURING CHD PATIENTS’ REHABILITATION, WITH CLINICAL SIGNS OF MODERATE CHF: EFFECTIVENESS OF ROSUVASTATIN AND EZETIMIBE by N. I. Tarasov, M. N. Sinkova, L. K. Isakov, N. B. Lebedeva, V. A. Shilov, A. T. Teplyakov

    Published 2016-06-01

    Aim. To study the efficacy of rosuvastatin and ezetimibe combination in patients with moderate clinical signs of chronic heart failure.Material and methods. We incllded outpatients (n=70) >40 y.o. with clinical picture of moderate heart failure (functional class by NYHA II), with comorbid dia...

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  3. 3
    STATINS IN THE TREATMENT AND PREVENTION OF CARDIOVASCULAR DISEASES: REPETITION OF THE PAST AND OPTIMISM FOR THE FUTURE

    STATINS IN THE TREATMENT AND PREVENTION OF CARDIOVASCULAR DISEASES: REPETITION OF THE PAST AND OPTIMISM FOR THE FUTURE by L. N. Malay

    Published 2015-09-01

    Statins, the most common drugs for reduction in lipid levels, are “strategic” medicinal products for the treatment and prevention of cardiovascular diseases caused by atherosclerosis. The milestones of lipid-lowering therapy history are presented as well as its contemporary aims and their implementa...

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  4. 4
    Population Pharmacokinetics and Pharmacodynamics with Enterohepatic Recirculation of Co-Medication of Rosuvastatin and Ezetimibe

    Population Pharmacokinetics and Pharmacodynamics with Enterohepatic Recirculation of Co-Medication of Rosuvastatin and Ezetimibe by An H, Shin D

    Published 2025-06-01

    Hyungmi An,1 Dongseong Shin2 1Department of Statistics and Data Science, Korea National Open University, Seoul, Korea; 2Department of Clinical Pharmacology and Therapeutics, Gil Medical Center, Gachon University College of Medicine, Incheon, KoreaCorrespondence: Dongseong Shin, Department of Clinica...

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  5. 5
    Modern views on clinical and economical effectiveness of rosuvastatin

    Modern views on clinical and economical effectiveness of rosuvastatin by S. K. Zyryanov, Yu. B. Belousov

    Published 2008-02-01

    Clinical trial and meta-analyis data demonstrate the important role of lipid-lowering therapy in reducing the risk of coronary heart disease (CHD) complications and CHD death. Practitioners need additional information to select from the already available statins the one that is not only effective an...

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  6. 6
    LIPID-LOWERING EFFICACY OF ROSUVASTATIN COMPARED WITH OTHER STATINS

    LIPID-LOWERING EFFICACY OF ROSUVASTATIN COMPARED WITH OTHER STATINS by A. N. Meshkov

    Published 2015-12-01

    Assessment of lipid-lowering effect of rosuvastatin is presented, as well as the main results of the study of rosuvastatin therapy efficacy , in comparison with other statins, received in controlled clinical trials of the GALAXY program: COMETS, LUNAR, MERCURY-I, SOLAR, STELLAR.

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  7. 7
    Statin Therapy and Cognitive Impairment: Benefit or Harm?

    Statin Therapy and Cognitive Impairment: Benefit or Harm? by O. D. Ostroumova, E. V. Chikh, E. V. Rebrova, A. Yu. Ryazanova

    Published 2018-09-01

    Statins are now widely used drugs for the treatment of dyslipidemia, effective drugs for lowering the level of low-density lipoprotein cholesterol, and also for reducing the risk of cardiovascular and cerebrovascular events. It is believed that statins are well tolerated. However, the potential rela...

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  8. 8
    STATINS AND MYOPATHY: MOLECULAR MECHANISMS

    STATINS AND MYOPATHY: MOLECULAR MECHANISMS by O. M. Drapkina, E. M. Chernova, O. N. Korneeva

    Published 2015-12-01

    The safety of statin therapy is considered. In particular the reasons of a complication such as myopathy are discussed in detail. The molecular mechanisms of statin myopathy , as well as its risk factors are presented. The role of coenzyme Q10 in the myopathy development and coenzyme Q10 application...

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  9. 9
    The problem of choice: original drug or generic? Emphasis on rosuvastatin

    The problem of choice: original drug or generic? Emphasis on rosuvastatin by O. A. Polyakova, O. D. Ostroumova

    Published 2022-05-01

    An increase in the life expectancy of the population and the number of polymorbid patients with a combination of two or more diseases in different age categories, including among young people, has led to a significant increase in the cost of medical care in the field of public health. The transition...

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  10. 10
    Therapeutic Options for the Single Pill Combination of Lisinopril, Amlodipine and Rosuvastatin: a Systematic Review

    Therapeutic Options for the Single Pill Combination of Lisinopril, Amlodipine and Rosuvastatin: a Systematic Review by S. R. Gilyarevsky, M. V. Golshmid, N. G. Bendeliani

    Published 2022-09-01

    Aim. To evaluate the effect of taking a single pill combination of amlodipine, lisinopril and rosuvastatin on blood pressure (BP) and low-density lipoprotein cholesterol (LDL-C) in hypertensive patients with or without severe hypercholesterolemia.Material and methods. Articles published in Russian w...

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  11. 11
    Rosuvastatin safety and efficacy in coronary heart disease patients

    Rosuvastatin safety and efficacy in coronary heart disease patients by I. V. Sergienko, M. V. Ezhov, V. P. Masenko

    Published 2006-10-01

    Aim. To study rosuvastatin safety and effects on lipid profile (LP) in coronary heart disease (CHD) patients. Material and methods. The study included 30 males (mean age 57±9 years) with diagnosed CHD, Functional Class II-III stable effort angina, receiving adequate basic therapy. In all participant...

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  12. 12
    USE OF ROSUVASTATIN AS A GEROPROTECTOR IN PEOPLE ENGAGED IN NATURAL GAS PRODUCING

    USE OF ROSUVASTATIN AS A GEROPROTECTOR IN PEOPLE ENGAGED IN NATURAL GAS PRODUCING by A. T. Abdrashitova, T. N. Panova, I. A. Belolapenko, M. V. Frenkel

    Published 2016-01-01

    Background. Prolong contact with manufacturing factors of gas producing, in particular hydrogen sulfide, results in dysfunction of various organs and systems, including immune system, which is involved in regulation of the aging process activity. Absence of effective geropreventive means creates the...

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  13. 13
    Short Term Comparison Between Safety and Efficacy of Rosuvastatin 40 mg and Atorvastatin 80 mg in Patients with Acute Coronary Syndrome

    Short Term Comparison Between Safety and Efficacy of Rosuvastatin 40 mg and Atorvastatin 80 mg in Patients with Acute Coronary Syndrome by Sh. A. Mostafa, Kh. Elrabat, M. Mahrous, M. Kamal

    Published 2018-11-01

    Background. Dyslipidemia is one of the most serious modifiable risk factors for acute coronary  syndrome which is the most leading cause of mortality and morbidity worldwide.Aim. To assess the short-term safety and efficacy of full dose rosuvastatin and atorvastatin in patients with acute coronary ...

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  14. 14
    Comparative effectiveness of different methods of prescribing rosuvastatin and ezetimibe in combination with PCSK9 inhibitors

    Comparative effectiveness of different methods of prescribing rosuvastatin and ezetimibe in combination with PCSK9 inhibitors by A. A. Kuznetsov, G. S. Mal, I. A. Saraev

    Published 2024-06-01

    Objective: comparative evaluation of the effectiveness of combined lipid-lowering therapy with rosuvastatin and ezetimibe in fixed and separate combinations with PCSK9 inhibitors in patients with very high cardiovascular risk.Materials and methods: 65 study participants were divided into 2 groups de...

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  15. 15
    UP TO DATE STATINS IN PRIMARY AND SECONDARY PREVENTION OF CARDIOVASCULAR DISEASES

    UP TO DATE STATINS IN PRIMARY AND SECONDARY PREVENTION OF CARDIOVASCULAR DISEASES by N. F. Puchin'yan, Ya. P. Dovgalevskiy, A. V. Panina

    Published 2015-12-01

    Early and aggressive treatment of patients with risk factors and clinically manifest cardiovascular diseases is one of the priorities of modern medicine. This therapy usually consists of several components according to multifactor origin of cardiovascular disease (CVD). Correction of lipid metabolis...

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  16. 16
    LIPID-LOWERING THERAPY IN OUTPATIENT PRACTICE (ACCORDING TO THE ARGO-2 STUDY)

    LIPID-LOWERING THERAPY IN OUTPATIENT PRACTICE (ACCORDING TO THE ARGO-2 STUDY) by N. M. Akhmedzhanov, D. V. Nebieridze, A. S. Safaryan, V. A. Vygodin, A. Yu. Shuraev, A. N. Tkacheva, A. S. Lishuta

    Published 2016-05-01

    Aim. To study the features of lipid-lowering therapy with rosuvastatin in high and very high cardiovascular risk patients in real outpatient practice.Material and methods. Patients ≥30 years, visited internists or cardiologists of district outpatient clinics in the period from October 2013 to July 2...

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  17. 17
    ATHEROSCLEROSIS: HOW TO START UP A "COUNT DOWN" CLOCK? WE DON'T KNOW, WE CAN NOT OR WE DO NOT WANT?

    ATHEROSCLEROSIS: HOW TO START UP A "COUNT DOWN" CLOCK? WE DON'T KNOW, WE CAN NOT OR WE DO NOT WANT? by L. N. Malay

    Published 2016-01-01

    Clinical cases of long-term use of rosuvastatin are presented with an estimation of its effect on the soft end (lipid profile) and hard end (number of heart attacks, strokes, heart failure, hospitalization for cardiovascular causes) points are given. The results of studies on rosuvastatin (ASTEROID,...

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  18. 18
    Comparison of Simvastatin and Rosuvastatin in Oxidation and Antioxidant Levels in Male Rabbits Infected with Experimental Lipid Disorder

    Comparison of Simvastatin and Rosuvastatin in Oxidation and Antioxidant Levels in Male Rabbits Infected with Experimental Lipid Disorder by Maysam Ibrahim Mahdi Al-Naisani, Mostafa Ali Abdulrahman, Rafah Razooq Hameed

    Published 2019-11-01

    The study was carried out in the animal house of Samarra University, This study included evaluation of two drugs as antioxidants outside the body. As well as comparing the effect each of them on oxidation and antioxidant of infected male rabbits with experimental lipid disorder by treated them with...

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  19. 19
    OBSERVATIONAL TRAILS IN LIPIDOLOGY

    OBSERVATIONAL TRAILS IN LIPIDOLOGY by S. A. Shalnova

    Published 2016-01-01

    Approaches to the evaluation of drug efficacy and safety are discussed. The specifics of clinical and observational trails are presented. The trail data on statins efficacy and safety are held up as a model.

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  20. 20
    Rosuvastatin ameliorates obesity-associated insulin resistance in high-fat diet-fed mice by modulating the gut microbiota and gut metabolites

    Rosuvastatin ameliorates obesity-associated insulin resistance in high-fat diet-fed mice by modulating the gut microbiota and gut metabolites by Chao Yao, Xin Xue, Yunxi Jia, Min Li, Lu Zhang, Hong Yuan, Huiting Xue, Ruiping Hu

    Published 2025-06-01

    IntroductionInsulin resistance (IR) underlies metabolic diseases such as obesity and diabetes. Statins are lipid-lowering drugs that have also been studied to improve insulin resistance, but the mechanism is not well understood. Metagenomics and metabolomics were used to analyze the main species and...

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