Search Results - "pyrazole"

This research includes synthesis of new derivatives of benzimidazole , the compound (A1*) prepared by reaction of o-phenylene diamine with carbon disulfide in alcoholic potassium hydroxide. Then the compound (A1*) was reaction with ethyl chloroacetate and potassium hydroxide to give ester (A2*). Th...

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The research included the preparation of new pyrazole derivatives from the condensation of the benzoyl acetone with carboxylic acid hydrazide in ethanal as a solvent. This reaction included two steps from the tetra surfaces nucleophilic addition and cyclisation process in second step. The pyrazole...

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Pain represents a primary symptom of numerous diseases and conditions, affecting millions of people worldwide. Effective analgesic medications can alleviate or eliminate pain, thereby enhancing patients’ quality of life and assisting them in resuming normal physical and social activities. However, s...

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This research included the preparation of new pyrazole derivatives from the condensation of the benzoyl acetone with carboxylic acid hydrazide in ethanol as a solvent. The reaction included two steps from the tetra surfaces nucleophilic addition and cyclisation process in second step. The pyrazole...

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In the title compound, 0.638C23H16BrF3N2·0.362C23H17F3N2, the Br atom has been partially replaced by an H atom by reaction with NaH. In the crystal, pairwise C—H...Br hydrogen bonds link the molecules into centrosymmetric dimers, enclosing R22(16) ring motifs. A Hirshfeld surface analysis indicates...

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<b>Background:</b> Natural products play a crucial role in cancer treatment due to their ability to selectively target cancer cells. Andrographolide, a major constituent of <i>Andrographis paniculata</i>, exhibits potential anticancer properties. Considering the pharmacologic...

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A series of new heterocyclic derivatives A5-A15 have been synthesized using 4-(toluene-4-sulfinylamino)-benzoic acid ethyl ester A2 as a predecessor. This compound A2 was successfully used in synthesis of some new derivatives of oxadiazole, pyrazole, triazole, thiadiazole, thiazole and fused hetero...

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<i>N</i>-(3-(<i>tert</i>-Butyl)-1-methyl-1<i>H</i>-pyrazol-5-yl)-4-methyl-<i>N</i>-tosylbenzenesulfonamide was efficiently synthesized in good yield through a triethylamine-mediated sulfonamidation reaction of 3-(<i>tert</i>-butyl)-1-methyl...

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An important direction of modern pharmaceutical science is the creation of promising biologically active compounds, which in the hands of scientists can be transformed into effective medicinal products. Heterocyclic compounds are the undisputed leader in solving this problem. A well-known fact and a...

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Three previously synthesized ketene dithioacetals were used as intermediates to obtain four nucleophiles to synthesize ten tetra-substituted pyrazoles (<b>11</b>–<b>20</b>). This was achieved through microwave irradiation in ethanol as the solvent, yielding superb results ran...

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Carboxylic acids and their derivatives are an important component of many biological processes. For example, they can be used to create new medicines that can be useful in the fight against various diseases. Additionally, compounds containing a thiazole moiety may possess beneficial properties in pr...

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Pyrazole and 1,2,4-triazole derivatives play an important strategic role in modern medicine and pharmacy. This fact is due to the significant possibilities of chemical modification and significant pharmacological potential among the derivatives of these heterocycles. The introduction of 1,2,4-tria...

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The problems associated with TNT necessitate the development of novel melt-castable compounds with melting points between 70 and 120 °C, a crucial endeavor in the field of energetic materials. This study introduces a promising melt-castable explosive based on nitropyrazole, whose melt-castable prope...

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Abstract The present study focuses on the iodination of pyrazoles mediated by cadmium (II) acetate. The objects of research were compounds with pyrazole rings substituted by N‐propargyl, C, N‐alkyl groups. Depending on the molar ratios of the reagents effective ways of obtaining mono‐ and triiodo‐su...

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The combination of pyrazole and 1,2,4-triazole fragments in one structure makes it possible to achieve some success in creating potential biologically active compounds. Various factors contribute to this process. Among them, we can note the significant possibilities of chemical transformation involv...

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The investigation of the antifungal activity of promising new compound of some pyrazole-3-carboxamides containing the ion of silver, against clinical isolates of Candida spp. by means micromethod two-fold serial dilution in liquid medium was the aim of the study. The results of an in-depth study of...

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Synthesis of 2-mercaptobenzothiazole (A1) is performed from the reaction of  o-aminothiophenol and carbon disulfide CS2 in ethanol under basic condition. Compound (A1)  is reacted with chloro acetyl chloride to give compound (A2). Hydrazide acid compound (A3) is obtained from the reaction of compoun...

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Heterocyclic compounds remain the most promising group of compounds, through which the new drugs with characteristic list of properties are successfully created. Examples of this systems are 1,2,4-triazole and pyrazole. The presence in one molecule structure of fragments of two different azaheterocy...

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Many complexes of 3,5-dimethyl-1H-pyrazol-1-yl phenyl methanone with Cr(III), Co(II), Ni(II), Cu(II) and Cd(II) were synthesized and characterized by FT-IR, UV/visible spectra, elemental analysis, room temperature magnetic susceptibility and molar conductivity. Cd(II) complex was expected to have t...

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Modeling of Michael addition of pyrazole to cinnamaldehyde in the presence of six thiourea catalysts has been done at the DFT (B3LYP/6-31+G(d,p)) level. Four catalysts incorporating 2-pyridyl moiety are found to exhibit bifunctional dual activation by encapsulating pyrazole molecule in the cavity of...

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