Kết quả tìm kiếm - "proteomics"

Radiotherapy resistance represents a critical aspect of cancer treatment, and molecular characterization is needed to explore the pathways and mechanisms involved. DNA repair, hypoxia, metabolic reprogramming, apoptosis, tumor microenvironment modulation, and activation of cancer stem cells are the...

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Peri- and postmenopausal women often experience unexplained weight gain despite maintaining consistent dietary and lifestyle habits. While the biological mechanisms underlying this phenomenon remain poorly understood, physiological and pathophysiological changes during the menopausal transition are...

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Modern methods of diagnosis and treatment of infectious diseases should be based on reliable data obtained through various methods of laboratory research. The main characteristics of the methods used are high sensitivity (the ability to analyze a small amount of sample, 10–6–10–4 g/ml), selectivity,...

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Proteomics has recently found wide application to account for the molecular mechanisms of cancer and to search for biomarkers that may be used to diagnose and/or predict the development of the disease. The paper briefly reviews proteomic studies to detect ovarian cancer biomarkers, by taking into ac...

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Trichoderma is a fungal genus of great and demonstrable biotechnological value, but its genome is poorly surveyed compared with other model microorganisms. Due to their ubiquity and rapid substrate colonization, Trichoderma species have been widely used as biocontrol organisms for agriculture, and t...

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Summary: Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive disease with limited therapeutic options. While genome profiling has benefitted clinical decision-making in many cancer types, PDAC remains among the most lethal solid cancers and has relatively few clinically actionable molecul...

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Summary: Here, we present a protocol for the tandem enrichment of ubiquitinated, phosphorylated, and glycosylated peptides from one sample using the SCASP-PTM (SDS-cyclodextrin-assisted sample preparation-post-translational modification) approach. We detail the steps for preparing samples for protei...

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Drought stresses are unfavorableenvironmentalfactors that affect crop growth especially in the early stagesof germination. Seed germination is a complex process that involves three main phases that in phases before radicle protrusion (second germination phase) many process was occurred in embryo axe...

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Camel milk exosomes from colostrum (C) and mature milk (M) were characterized using proteomics and lipidomics to elucidate their compositional and functional differences. Isolated exosomes exhibited round and cup-like concave spheres of 30 to 150 nm and higher TSG101 expression in colostrum. Proteom...

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Summary: Mouse syngeneic models serve as indispensable tools for elucidating tumor-immune interactions and assessing immunotherapy efficacy. In this study, we first conducted a comprehensive evaluation of six label-free protein quantification pipelines across 12 mouse syngeneic models, revealing tha...

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<b>Background/Objectives</b>: Rheumatoid arthritis (RA) and osteoarthritis (OA) are highly prevalent diseases and their pathophysiology, diagnosis and treatment continue to be challenging. The aim of this study was to characterize and differentiate the profiles of the serum extracellular...

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The paper presents the studies on the autolytic transformations in pork and beef samples by proteomic methods. The changes in the protein fractions were analyzed by one-dimensional and two- dimensional electrophoresis with the following identification by mass-spectrometric methods. The changes in mu...

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Aspergillus fumigatus is an opportunistic fungal pathogen of the human airway that can cause a variety of chronic infections, typically in the context of pre-existing lung damage. The interaction of A. fumigatus with ex-vivo pig lung (EVPL) samples was characterized at the proteomic level to provide...

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Biocompatibility remains a central issue for introducing biomaterials and nanomedicines into the clinic, requiring safety, functionality, toxicity prevention, and the control of foreign body reactions. Therefore, it is necessary to evaluate multiple biomaterial parameters and molecular interactions...

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Cow milk is a widespread food, but several children are allergic to it – chiefly because of adverse reactions to its proteins. Nutritionally valid, hypoallergenic surrogates are highly sought after, and among them donkey milk is prized for its tolerability and human-like composition. Still, donkeys...

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Fatty liver is a major metabolic disease in periparturient dairy goats. Protein ubiquitination, a type of dynamic and multifaceted post-translational modification, plays an important role in metabolism by regulating the stability and function of target proteins. However, the hepatic protein ubiquiti...

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In order to improve beef color and color stability, step-chilling (SC) was applied on excised bovine longissimus lumborum muscle, with chilling starting at 0–4°C for 5 h, then holding the temperature at 12–18°C for 6 h, followed by 0–4°C again until 24 h post-mortem. pH and temperature were measured...

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Abstract. The aim of present study was to analyze the most commonly detected blood plasma immune proteins, that reflect molecular pathways in development of infectious endocarditis of native valves, together with analysis of marker proteins of disease on the base of modern technological platform for...

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Background and purpose: Gastric cancer, as one of the most common malignant tumors, requires early diagnosis and treatment to improve patient prognosis. This study, based on serum quantitative proteomics research of early-stage gastric cancer patients and non-gastric cancer patients, aims to identif...

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Abstract Compared with 2D monolayers, 3D models more closely mimic native muscle tissue and allow functional measurements. A more complete understanding of how culture conditions and duration affect myotube maturity/function is crucial for validating the transition to 3D systems. Human skeletal musc...

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