Search Results - "protective efficacy"

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  1. 1
    Intranasal trivalent candidate vaccine elicits broad humoral and cellular immunity against pneumococcal pneumonia

    Intranasal trivalent candidate vaccine elicits broad humoral and cellular immunity against pneumococcal pneumonia by Fangyu Ren, Fangyu Ren, Luyun Huang, Luyun Huang, Shilu Luo, Shilu Luo, Changjin Liu, Changjin Liu, Xianlian Chen, Xianlian Chen, Xin Yao, Xin Yao, Qiqi Linghu, Qiqi Linghu, Huaqin Hu, Huaqin Hu, Xiaoyu Huang, Xiaoyu Huang, Yuanqin Hu, Yuanqin Hu, Jian Huang, Jian Huang, Xun Min, Xun Min

    Published 2025-06-01

    Streptococcus pneumoniae is an important pathogen causing public health problems worldwide. Existing pneumococcal vaccines provide protection against only a few of the more than 100 pneumococcal serotypes, highlighting the urgent need for new preventive strategies. Pneumococcal protein vaccines have...

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  2. 2
    IL-24 Is a Promising Molecular Adjuvant for Enhancing Protective Immunity Induced by DNA Vaccination Against <i>Toxoplasma gondii</i>

    IL-24 Is a Promising Molecular Adjuvant for Enhancing Protective Immunity Induced by DNA Vaccination Against <i>Toxoplasma gondii</i> by Bohuai Xu, Xiuqiang Zhang, Yaowen Wang, Jia Chen

    Published 2025-07-01

    <i>Toxoplasma gondii</i>, a parasitic protozoan, causes zoonotic infections with severe health impacts in humans and warm-blooded animals, underscoring the urgent need for effective vaccines to control these infections. In this study, a DNA vaccine encoding TgROP5, TgROP18, TgGRA7, TgGRA...

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  3. 3
    Preclinical evaluation of a live avian metapneumovirus subtype B vaccine strain with cross-protective efficacy in chickens

    Preclinical evaluation of a live avian metapneumovirus subtype B vaccine strain with cross-protective efficacy in chickens by Sae-Jin Kim, Hyun-Jin Kim, Yun-Hee Noh, Ho-Keun Won, Seung-Min Hong, In-Joong Yoon, Kang-Seuk Choi

    Published 2025-08-01

    Avian metapneumovirus (aMPV) infection is an important respiratory disease that causes significant economic loss in the poultry industry. Here, we aimed to develop an effective live aMPV subtype B vaccine strain suitable for mass vaccination of poultry farms to achieve herd immunity. The wild-type v...

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  4. 4
    Intranasal Administration of Cold-Adapted Live-Attenuated Eurasian Avian-like H1N1 Vaccine Candidate Confers Protection Against Different-Lineage H1N1 Viruses in Mice

    Intranasal Administration of Cold-Adapted Live-Attenuated Eurasian Avian-like H1N1 Vaccine Candidate Confers Protection Against Different-Lineage H1N1 Viruses in Mice by Qiu Zhong, Zuchen Song, Fei Meng, Yanwen Wang, Yijie Zhang, Zijian Feng, Yali Zhang, Yujia Zhai, Yan Chen, Chuanling Qiao, Hualan Chen, Huanliang Yang

    Published 2025-05-01

    Background/Objectives: Eurasian avian-like (EA) H1N1 swine influenza viruses, with their persistent evolution and zoonotic potential, seriously threaten both swine and human health. The objective was to develop an effective vaccine against these viruses. Methods: A cold-adapted, temperature-sensitiv...

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  5. 5
    Safety, immunogenicity, and protective efficacy of the intranasal live pertussis vaccine GamLPV in an infant monkey model (<i>Papio hamadryas</i>)

    Safety, immunogenicity, and protective efficacy of the intranasal live pertussis vaccine GamLPV in an infant monkey model (<i>Papio hamadryas</i>) by D. T. Kubrava, A. Yu. Medkova, A. Z. Matua, I. G. Kondzariya, A. A. Amichba, Kh. Z. Trapsh, L. V. Gamgiya, S. G. Kulikov, L. N. Sinyashina, Z. Ya. Mikvabiya, G. I. Karataev

    Published 2024-12-01

    INTRODUCTION. The current progressive increase in pertussis incidence and infant mortality rates is due to the insufficient effectiveness of existing vaccines, both in Russia and worldwide. Previous clinical trials showed that healthy adult volunteers developed long-term antibacterial immunity after...

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  6. 6
    Protective efficacy of an H5/H7 trivalent inactivated vaccine produced from Re-11, Re-12, and H7-Re2 strains against challenge with different H5 and H7 viruses in chickens

    Protective efficacy of an H5/H7 trivalent inactivated vaccine produced from Re-11, Re-12, and H7-Re2 strains against challenge with different H5 and H7 viruses in chickens by Xian-ying ZENG, Xiao-han CHEN, Shu-jie MA, Jiao-jiao WU, Hong-mei BAO, Shu-xin PAN, Yan-jing LIU, Guo-hua DENG, Jian-zhong SHI, Pu-cheng CHEN, Yong-ping JIANG, Yan-bing LI, Jing-lei HU, Tong LU, Sheng-gang MAO, Xing-fu GUO, Jing-li LIU, Guo-bin TIAN, Hua-lan CHEN

    Published 2020-09-01

    We developed an H5/H7 trivalent inactivated vaccine by using Re-11, Re-12, and H7-Re2 vaccine seed viruses, which were generated by reverse genetics and derived their HA genes from A/duck/Guizhou/S4184/2017(H5N6) (DK/GZ/S4184/17) (a clade 2.3.4.4d virus), A/chicken/Liaoning/SD007/2017(H5N1) (CK/LN/S...

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  7. 7
    An Evaluation of the Safety, Immunogenicity, and Protective Efficacy of a Combined Diphtheria–Tetanus–Acellular Pertussis, <i>Haemophilus influenzae</i> Type b, and ACYW135 Meningococcal Conjugate Vaccine in Murine and Rat Models

    An Evaluation of the Safety, Immunogenicity, and Protective Efficacy of a Combined Diphtheria–Tetanus–Acellular Pertussis, <i>Haemophilus influenzae</i> Type b, and ACYW135 Meningo... by Xiuwen Sui, Zhujun Shao, Yuanyuan Ji, Hairui Wang, Qingfu Xu, Bochao Wei, Zhuojun Duan, Chang Wang, Ying Yang, Jiayu Zhao, Tao Zhu

    Published 2025-07-01

    <b>Background</b>: The combined diphtheria–tetanus–acellular pertussis (three-component), <i>Haemophilus influenzae</i> type b (Hib, conjugate), and ACYW135 meningococcal (conjugate) vaccine (DTaP-Hib-MCV4) offers a promising alternative to single-component vaccines, potentia...

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  8. 8
    Protective efficacy of an H5/H7 trivalent inactivated vaccine (H5-Re13, H5-Re14, and H7-Re4 strains) in chickens, ducks, and geese against newly detected H5N1, H5N6, H5N8, and H7N9 viruses

    Protective efficacy of an H5/H7 trivalent inactivated vaccine (H5-Re13, H5-Re14, and H7-Re4 strains) in chickens, ducks, and geese against newly detected H5N1, H5N6, H5N8, and H7N9... by Xian-ying ZENG, Xin-wen HE, Fei MENG, Qi MA, Yan WANG, Hong-mei BAO, Yan-jing LIU, Guo-hua DENG, Jian-zhong SHI, Yan-bing LI, Guo-bin TIAN, Hua-lan CHEN

    Published 2022-07-01

    Some H5 viruses isolated in poultry or wild birds between 2020 and 2021 were found to be antigenically different from the vaccine strains (H5-Re11 and H5-Re12) used in China. In this study, we generated three new recombinant vaccine seed viruses by using reverse genetics and used them for vaccine pr...

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  9. 9
    Study of the protective efficacy of CombiMab-2 against human immunodeficiency virus type 1 in mice humanised with CD4<sup>+</sup> T-lymphocytes

    Study of the protective efficacy of CombiMab-2 against human immunodeficiency virus type 1 in mice humanised with CD4<sup>+</sup> T-lymphocytes by D. S. Leontyev, F. A. Urusov, D. V. Glazkova, B. V. Belugin, O. V. Orlova, R. R. Mintaev, G. M. Tsyganova, E. V. Bogoslovskaya, G. A. Shipulin

    Published 2024-10-01

    INTRODUCTION. Despite existing treatment methods, complete eradication of human immunodeficiency virus (HIV) infection remains an unattainable goal due to the high variability of HIV type 1 (HIV-1). HIV infection necessitates life-long administration of antiretroviral medicinal products, which cause...

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