Search Results - "preeclampsia"

La preeclampsia es una enfermedad multisistémica, exclusiva del ser humano, que afecta del 2-4% de la totalidad de los embarazos. En 2022, en Argentina fue la principal causa de muerte materna. Las estrategias de prevención de la preeclampsia más efectivas incluyen la administración de aspirina, la...

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Background: Preeclampsia is a vascular complication of pregnancy with limited therapeutic options. It is associated with hypertension and an increase in angiogenic factor soluble fms-like tyrosine kinase-1 (sFlt-1)/placental growth factor. Based on its onset, preclampsia can be categorized into earl...

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The success in modern biology has significantly enriched scientific understanding of the pathogenetic basis underlying some diseases, including obstetric and gynecological practice. Despite this, the etiology and pathogenesis of some conditions are not yet fully elucidated. One of the approaches is...

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Background: Preeclampsia is a condition characterized by new-onset hypertension during pregnancy, which can lead to various complications for both the mother and baby. It is categorized into early-onset preeclampsia (EO-PE) and late-onset preeclampsia (LO-PE) based on the timing of onset, each havin...

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Due to the fact that preeclampsia remains one of the difficult issues in obstetrics and is one of the main reasons of maternal and perinatal morbidity and mortality all over the world, the data of late years about the possibility to predict this complication is summarized in the review. The authors...

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Abstract. During the passage through the utero-placental circulation, peripheral blood monocytes are exposed to action of various soluble placenta-derived factors. Subsequently these cells migrate to placental tissue and play a key role in regulation of placental growth and development. We investiga...

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Hypertensive disorders of pregnancy, including pre-existing and gestational hypertension, preeclampsia and eclampsia, complicate up to 10% of pregnancies and represent a significant cause of maternal and perinatal morbidity and mortality. Despite some differences in guidelines, there is consensus th...

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This study is to evaluate plasma levels of several cytokines in preeclamptic pregnancies compared to those of healthy pregnancies. Ninety pregnant women with preeclampsia (37 mild & 53 severe) and thirty healthy pregnant women were enrolled in the study. Blood samples were taken and plasma level...

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Preeclampsia is a serious complication of pregnancy and one of the leading causes of maternal mortality. According to modern concepts, the key link in the pathogenesis of preeclampsia is an endothelial dysfunction leadind to persistent prothrombotic hemostasis state. Markers and predictors of preecl...

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Pre-eclampsia is a major cause of maternal and perinatal morbidity and mortality. Alpha_fetoprotein is measured in pregnant women, as a screening test for  pre-eclampsia.This study aimed to examine  the maternal serum alpha-fetoprotein at 12, 22 and 32 weeks ’gestation in singleton pregnancies and...

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Aim. Justification of control of reconvalescence and individual rehabilitation in women who underwent severe preeclampsia (PE). Materials and methods. A prospective, non-randomized, controlled, open-label, nosocomial study was conducted in the period of 2016-2017. 170 women participated: 100 women w...

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Motivated by illuminating the underlying mechanisms of preeclampsia, we develop a changepoint detection-based general and versatile methodology that can be applied to any experimental model, effectively addressing the challenges of high uncertainty produced by experimental interventions, intrinsic h...

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Abstract. Мonocytes in feto-placental circulation are exposed to factors secreted by placental tissue. These factors influence monocyte functions in pregnancy. In present study, an in vitro model (monocyte-like THP-1 cells) was used for assessing effects of soluble placental factors obtained from wo...

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Methylated analogs of L-arginine - asymmetric dimetilarginin (ADMA) and monometilarginin (L-NMMA) - are endogenous inhibitors of endothelial NO-synthase (eNOS). ADMA level in maternal plasma is increased in women with preeclampsia. The high level of ADMA is one of the predictors of preeclampsia. L-a...

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<i>Background and Objectives</i>: Air pollutants have been shown to affect hypertensive disorders and placental hypoxia due to vasoconstriction, inflammation, and oxidative stress. The objective of this study was to evaluate whether high levels of maternal exposure to heavy metals during...

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Objective. To evaluate the efficiency of antithrombotic therapy to prevent repeated preeclampsia in patients with thrombophilia. Subject and methods. A prospective clinical study was conducted 66 patients with thrombophilia (genetic, acquired or concomitant) and with history of preeclampsia: 35 pati...

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Objective. To evaluate the efficiency of antithrombotic therapy to prevent repeated preeclampsia in patients with thrombophilia. Subject and methods. A prospective clinical study was conducted 66 patients with thrombophilia (genetic, acquired or concomitant) and with history of preeclampsia: 35 pati...

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Background: Preeclampsia (PE) is a condition that is specific to pregnancy and has a substantial impact on the morbidity and mortality of the mother and the fetus worldwide. Currently, various markers may serve as possible predictors or markers for illness severity. Objectives: The present study...

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Podocalyxin (PCX) is a glycoprotein member of the CD34 transmembrane sialomucin family and covers the surface of podocytes. It is assumed to be a marker of glomerular endothelial injury. In conditions, podocalyxin excretion in the urine is increased as a result of podocyte injury. Recent studies sho...

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Objective Autism spectrum disorder (ASD) has multifactorial origins, some related to the prenatal period. Preeclampsia, a serious pregnancy complication, is also multifactorial. This study aimed to explore the potential association between preeclampsia and ASD in a diverse population.Study Design A...

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