Search Results - "paracetamol"

Introduction : Paracetamol is an effective analgesic to relieve mild to moderate pain when it is used in therapeutic doses. Codeine is an opioid analgesic to relieve moderate to severe pain. Both are metabolized in the liver and have different mechanisms in the treatment of pain. The use of paraceta...

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BACKGROUND Currently, despite the optimization of diagnostic methods in order to predict the development of liver damage, improvement of treatment protocols, paracetamol poisoning is a serious problem in medicine, being the most common cause of acute liver failure worldwide.AIM OF STUDY To determine...

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Background. Acetylcysteine (ACC) is an effective antidote for paracetamol poisoning. There are various schemes for its application. At the same time, there is currently no information about the most priority of them in this pathology. Few studies indicate the effectiveness of the 12-hour protocol fo...

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A simple, and rapid spectrophotometric method for the estimation of paracetamol has been developed. The methods is based on diazotisation of 2,4-dichloroaniline followed by a coupling reaction with paracetamol in sodium hydroxide medium. All variables affecting the reaction conditions were carefully...

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Background: A combination of the analgesic drug Paracetamol and Codeine can be used in moderate to severe pain management. Both are classified into two different groups of analgesics, thus they have a different mechanism of action. The combination of Paracetamol and Codeine provides better potential...

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The quality of Paracetamol suppositories produced by domestic manufacturers has been investigated and their compliance with pharmacopoeial requirements has been established. Dissolution profile test of paracetamol suppositories of different producers has been carried out and nonequivalence of profil...

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Aronia melanocarpa fruit juice (AMFJ) is very rich in polyphenolic compounds. Quercetin is a naturally occurring flavonoid, one of AMFJ polyphenols. The aim of the present study was to investigate the effect of AMFJ in comparison with quercetin in a model of paracetamol-induced hepatotoxicity in rat...

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The possibility of formation of paracetamol of orthorhombic modification by the method of calorimetry is studied. The studies include technological experiments, optical microscopy, differential scanning calorimetry, X-ray diffraction and IR spectroscopy. It is found that in the result of temperature...

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Objective. To compare efficacy and safety of nimesulide and paracetamol in treatment of patients with osteoarthritis (OA) during 12 months. Material and methods. 40 women (mean age 66,8±5,1 years) with knee osteoarthritis (II-III stage according to Kellgren-Lawrence) having intensive pain (>4...

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Background: Oxidative stress is an imbalance between free radicals and antioxidants, characterized by increase in malodialdehyde (MDA) levels. Stress oxidative caused by paracetamol overdose consumption and can be a serious problem for the structure and liver cell function. Oxidative stress prevente...

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Background. The use of complexes of synthetic and herbal remedies as hepatoprotectors in the treatment of liver pathologies of various etiologies is an urgent task of pharmacology. A promising type of medicinal plant raw material is an extract of  Hippophaes rhamnoides leaves. The  hepatoprotective...

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The influence of hepatoprotector phospholipid nature Essentiale and Essenciale combination with succinic acid on the metabolism of liver injury caused by Paracetamol in rats has been investigated. As a result of therapy was decreased Paracetamol hepatotoxicity — in the blood reduced the aminotransfe...

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Development of method for determining the melting enthalpy of monotropic transitions and the activation energy of substances decomposition using highly thermally conductive inert material by differential scanning calorimetry and its practical use for determining the weight content of the active subs...

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Some of important drugs in Kurdistan Region are planned to be determined such as analgesics and antibiotics from different available companies. For the first stages Paracetamol, Aspirin, Chloramphenicol, Ibuprofen and Tetracycline drugs were examined and the real quantities determined were compared...

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Background: Oxidative stress is a condition which were free radicals harm biological molecules, like lipid, protein, and DNA. Consume paracetamol can increase oxidative stress, which can cause increased level of AST and ALT serum. Longan pericarp (Dimocarpus longan L.) is one of natural ingredients...

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Aim. In this research, we studied the parameters of blood biochemical analysis in rats with combined paracetamol-alcoholic liver injury after its pharmacological correction by newly synthesized partially hydrogenated pyridines (cyanothioacetamide derivatives).Materials and methods. 50 samples of new...

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Background: Liver is a vital organ performing major metabolic and detoxification reactions, which makes it very liable to damage and injury by a wide range of drugs and xenobiotics. Paracetamol (PCM) is an over-the-counter analgesic that is considered to be safe at therapeutic doses; however, gettin...

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Background. Paracetamol poisoning is common all over the world, including in Russia. In 20–25% of cases, a massive dose of the drug is observed: more than 30–40 g of paracetamol at a time.The aim of the study was to demonstrate the efficacy of using an increased doses of acetylcysteine in the treatm...

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The aim of this research was  develop and validate an analytical method by Uv spectrophotometric technique for quantitative determination of paracetamol (PAR), diclofenac or voltarine (DIC) and tramadol or tramal (TRA) in tablet dosage form, paracetamol analysis is based on the absorbance maxima we...

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Abstract Background The liver is a vital organ that detoxifies drugs and xenobiotics. However, breaking down toxins creates byproducts that can damage the liver. Silibinin possesses a proven hepatoprotective and antioxidant effect as it inhibits the free radicals produced from the metabolism of toxi...

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