Search Results - "observational studies"

The article discusses the main methods of evidence in modern medicine. Special attention is paid to randomized controlled trials and observational studies. The advantages of randomized controlled trials over observational studies are considered. A comparison of the informative value of randomized co...

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Aim. Development, testing and validation of the original questionnaire “Adherence Scale” (AS) in the PRIORITY and ANTEY observational studies (OS).Materials and methods. The OS PRIORITY assessed adherence to statins in 298 patients with high and very high cardiovascular risk for 3 months. The OS ANT...

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Observational cohort investigations are an effective way to study chronic diseases, including psoriatic arthritis, in clinical practice. One of the tools to support such research is registers that collect data related to various aspects of the disease and pharmacotherapy. This review provides inform...

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The data from the observational study of M. Fralick et al. were analyzed in the article. The authors analyzed a large database of patients with atrial fibrillation and concluded that rivaroxaban is inferior to apixaban in its ability to prevent ischemic stroke and systemic embolism and is more likel...

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Yihao Niu,1 Shengming Shi,1 Yongxia Chen,1 Shuangyuan Yang,1 Peiyu Yan,1,2,* Jiyou Kou3,* 1Faculty of Chinese Medicine, Macau University of Science and Technology, Macau, Macau SAR, People’s Republic of China; 2State Key Laboratory of Quality Research in Chinese Medicines, Ma...

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The role of randomized controlled trials (RCTs) and observational studies in evaluation of the efficacy and safety of cardiology drugs is compared in the article. The clear conclusion is made that RCTs are the basis of modern evidence-based medicine, and that they have no alternative. Observational ...

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Background and aim Patients with COPD and concurrent depression and/or anxiety are known to have an increased risk of exacerbations, morbidity, mortality, and deteriorated quality of life. Early detection of depression/anxiety may enable early interventions. The aims of this study were to describe t...

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Aim. To assess the percentage of the patients who receive lipid-lowering drug therapy and achieve target levels of low-density lipoprotein cholesterol (LDL–CH), in accordance with the recommendations by the Russian Cardiology Society (RCS) and the 4th Joint European Task Force (4JETF).Material and m...

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<b>Background:</b> Currently, no information exists on the clinical course of anti-topoisomerase I antibody (ATA)-positive limited cutaneous systemic sclerosis (lcSSc). We aimed to evaluate the incidence of and time to the development of interstitial lung disease (ILD), pulmonary hyperte...

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News of the European Society of Cardiology Congress (Rome, 2016) is reviewed. The results of recent randomized controlled trials, observational studies (registers) data, common problems in the presentation and interpretation of the reviewed data are discussed.

News of the European Society of Cardiology Congress (London, 2015) is presented. The results of recent randomized controlled trials and observational studies (registers) data are discussed.

The article describes the basic rules for conducting observational studies, in particular, registers. The principles of the assessment of its quality and impact on the results are discussed. The potential for evaluating therapeutic effect and side effects in randomized controlled trials (RCTs) and o...

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Safinamide is a monoamine oxidase B inhibitor that was approved in Europe in February 2015 to complement a stable dose of levodopa in monotherapy or in combination with other antiparkinsonian agents in adults affected by mid-stage or advanced Parkinson disease (PD) with fluctuations. It is character...

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Much medical research is observational. The reporting of observational studies is often of insufficient quality. Poor reporting hampers the assessment of the strengths and weaknesses of a study and the generalisability of its results. Taking into account empirical evidence and theoretical considerat...

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ABSTRACT Objective Inverse probability weighting is a fundamental and general methodology for estimating the causal effects of exposures and interventions, but standard approaches to constructing such weights are often suboptimal. Methods In this paper, we describe a recent approach for constructing...

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Randomized controlled trials (RCTs) are the gold standard for evaluating the causal effect of a treatment; however, they often have limited sample sizes and sometimes poor generalizability. On the other hand, non-randomized, observational data derived from large administrative databases have massive...

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Principles and fundamentals of proper presentation of observational epidemiological study results are focused. Principles of observational study publication developed by expert epidemiologists (STROBE statement) are explained in detail.

Introduction. As defined by the Food and Drug Administration, real-world data (RWD) is data related to a patient's health and/or health care delivery, usually collected from various sources as part of real-world clinical practice research.Objective: to describe the feasible and the most sought-...

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Abstract Objective To evaluate the adequacy of a pediatric hospital in a large city in the metropolitan region of Rio de Janeiro to the recommendations of the Brazilian Dietary Guidelines regarding the service provision contract, dietary prescription and aspects of the food environment. Methods...

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Introduction: The efficacy and safety of alemtuzumab for patients with relapsing–remitting multiple sclerosis (RRMS) have been demonstrated in clinical trials. However, due to the limitations of these studies, it is important to assess the effects of the drug in clinical practice. The purpose of thi...

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