Search Results - "nanocarrier"

Nagami kumquat (Fortunella margarita) fruit is susceptible to post-harvest damage due to P. digitatum infection, which reduces quality and shortens shelf life. This study aims to develop a chitosan-based edible coating enriched with Mandarin cv. Terigas essential oil nanoemulsion to inhibit the grow...

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Microneedle-mediated drug delivery systems (MDDS) have experienced robust growth in recent years, with designers leveraging their creativity to apply these systems for direct drug delivery to the skin, mucous membranes, blood vessel walls and even internal organs. In order to achieve precise drug de...

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CRISPR-Cas system permanently deletes any harmful gene-of-interest to combat cancer growth. Chitosan (CS) is a potential cancer therapeutic that mediates via PI3K/Akt/mTOR, MAPK and NF-kβ signaling pathway modulation. CS and its covalent derivatives have been designed as nanocarrier of CRISPR-Cas9 a...

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Nanoscale drugs differ in special physicochemical, biological, pharmacokinetic parameters. These properties can be used to provide targeted delivery, prolong the action of drugs, as well as reduce their side effects. An important problem that needs attention is the study of the potential risks arisi...

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Liming Song,1– 3 Yahui Wu,1– 3 Senfeng Zhao,1– 3 Yin Liu,1– 3 Zhipu Liu,1– 3 Yunpeng Zhai,1– 3 Jiahui Cao,1– 3 Yaning Xia,4 Ruopeng Liang,1– 3 Weijie Wang,1– 3 Rongtao Zhu,1– 3 Binghua Sun,5 Yupeng Shi,4 Yuling Sun1– 3 1Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospita...

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<b>Background/Objectives:</b> This study focused on developing an organic solvent-free formulation of phytantriol-based cubosomes for nifedipine delivery. It assessed the physicochemical properties and in vitro administration performance in pediatric nasogastric tubes and preliminarily e...

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Breast cancer stem cells (BCSCs) drive tumor formation and growth via self-renewal, differentiation, and high tumorigenic potential, and the persistence of BCSCs is an important cause of treatment failure in patients with breast cancer. In addition, the tumor microenvironment promotes the maintenanc...

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Liposomes represent a cornerstone of modern drug delivery systems due to their unique structural and physicochemical characteristics. Extensive research has refined their formulation, stability, and targeting capabilities, leading to numerous clinical applications, particularly in oncology. A key cl...

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Inflammatory skin diseases are highly prevalent conditions characterized by complex immune responses that result in skin tissue damage and pain, significantly impacting patients’ physical health. Traditional therapeutic approaches, including oral administration and injections, continue to exhibit in...

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Curcumin exhibits compromised bioavailability upon oral administration due to its inherent limitations, including low aqueous solubility, poor membrane permeability, and chemical instability. Inspired by the efficient mechanism by which viruses penetrate mucus and cells, we constructed an electrical...

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Lung cancer remains the leading cause of cancer‐related mortality worldwide, owing to its aggressive nature, late‐stage diagnosis, and resistance to conventional therapies. Gene therapy offers a promising alternative by modulating specific genetic pathways to target cancer cells while sparing health...

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Yuanyuan Wang, Tao Li, Hui Zhou, Chunyu Liu Department of Pharmacy, West China Hospital, Sichuan University, Chengdu, 610041, People’s Republic of ChinaCorrespondence: Chunyu Liu, Email 2608092067@qq.comAbstract: Photodynamic therapy (PDT), as a non-invasive treatment modality, has shown potential a...

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BackgroundThis study aimed to develop and evaluate SabiWhite-loaded ethosomes (SW-ETH) for topical application, focusing on improving stability, biocompatibility, and therapeutic efficacy. Ethosomal formulations are known for their enhanced drug delivery properties, making them suitable for skin inf...

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Nanocarriers derived from carbohydrate polymers offer a promising approach to overcoming the limitations of conventional cancer therapies, particularly by enhancing tumor targeting and enabling sustained drug release. A novel nanoemulsion based on Cyclodextrin, Zein, and TiO2 nanoparticles was devel...

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Chaoqun Sun,1,&amp;ast; Ju Chen,1,2,&amp;ast; Shuyou Bai,1,&amp;ast; Wenyu Liao,2 Junmin Chen,2 Weixiong Guo,1,3 Li Zeng,1 Lili Yu1 1Faculty of Chinese Medicine, Medical Sciences Division, Macau University of Science and Technology, Taipa, Macau, People’s Republic of China; 2Department o...

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Abstract Central nervous system (CNS) disorders are driven by complex genetic and epigenetic factors. While gene‐based interventions (siRNA, mRNA, CRISPR systems, etc.) hold transformative potential, their clinical application is severely constrained by inefficient delivery, especially across the bl...

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Ferritin is a ubiquitous cage-shaped protein found in living organisms. Beyond its fundamental role in iron homeostasis, ferritin demonstrates growing application value in food engineering, nanocarrier systems, and biomedicine, owing to its unique self-assembly properties, exceptional stability, and...

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Myriam González, Maria P Romero Escuela Politécnica Nacional, Departamento de Materiales, Quito, 170143, EcuadorCorrespondence: Maria P Romero, Escuela Politécnica Nacional, Departamento de Materiales, Quito, 170143, Ecuador, Email maria.romerom@epn.edu.ecAbstract: Carbon dots (CDs) have become vers...

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Irinotecan (IRI) is a water-soluble camptothecin derivative used to treat various types of cancers. However, its severe side effects and poor structural stability under physiological conditions have driven researchers to explore nanoparticle-based delivery systems to improve its efficiency and safet...

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Jiannan Ren,1,&amp;ast; Menglin Song,1,&amp;ast; Dongbing Ding,1,&amp;ast; Tianyun Lan,2 Yiquan Li,1 Rongpu Liang,1 Shengxin Huang,1 Guangchun Jiang,1 Jiarong You,1 Jianming Yang,1 Chi Chen,1 Weiyi Luan,3 Bekhzod Abdullaev,4 He Huang,1 Yang Zhao,1 Bo Wei1 1Department of Gastrointestinal...

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