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Inhibition of Bovine Enterovirus Infection by Magnolol via Modulating the Gut Microbiota in Mice
Published 2025-05-01Subjects: Get full textBovine enterovirus (BEV) infection is one of the important infectious diseases that cause digestive and respiratory symptoms in cattle, posing a significant threat to the cattle industry. Currently, no vaccines or therapeutic drugs are available for this disease. In our study, we utilized a mouse mo...
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Electroretinographic and Morphological Characterization of the Retina of Annexin A1 Knockout Mice
Published 2025-05-01Subjects: Get full textBackground/Objectives: The annexin A1 (AnxA1) protein has proven important in ocular disease homeostasis and holds great therapeutic promise. However, its role in the context of the healthy retina remains unknown. Therefore, this study used electroretinography (ERG) to investigate the role of endoge...
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CpG oligodeoxynucleotides and pan-serotype inhibitors control neurotropic dengue infection in novel immune competent neonatal mouse model
Published 2025-12-01Subjects: Get full textDengue virus (DENV) is a growing global public health threat. The lack of symptomatic immune-competent animal models for dengue has hindered the screening and development of effective therapeutics that can be used to control dengue virus replication and thereby control the progression to severe deng...
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Two strains of Toscana virus show different virulence and replication capacity in mice and cell culture models
Published 2025-12-01Subjects: Get full textToscana virus (TOSV), belonging to Phenuiviridae family, is circulating in most Mediterranean countries and is transmitted to humans by infected female sand flies. While most infections are asymptomatic, TOSV is considered as a leading cause of meningitis and encephalitis in humans during summer. Th...
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Characterization of an mRNA-Encoded Antibody Against Henipavirus
Published 2025-07-01Subjects: Get full textNipah and Hendra viruses are lethal zoonotic pathogens with no approved vaccines or therapeutics. mRNA produced via in vitro transcription enables endogenous protein expression and cost reduction. Here, we systematically screened natural and artificial untranslated regions (UTRs) and identified an o...
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Commentary: Local sympathetic nerve depletion does not alter vitiligo progression in a mouse model
Published 2025-07-01 Subjects: Get full text
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Intraperitoneal infection of A/J and CD1 mice with coxsackievirus B2 and its mutants
Published 2025-07-01Subjects: Get full textCoxsackieviruses (CVs) belong to the genus Enterovirus and family Picornaviridae. Mutants can arise within the replication cycle of RNA viruses. The prototype CVB2 Ohio-1 (CVB2/O) strain adapted to rhabdomyosarcoma (RD) cells induced cytolytic infection and showed three-point mutations in the genome...
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Observation of the Effects of Infrapatellar Fat Pad Excision on the Inflammatory Progression of Knee Osteoarthritis in Mice
Published 2025-05-01Subjects: Get full textYa Li,1,2,* Peizhi Lu,1,2,* Haoyu Yao,2 Shuo Yang,2 Bizhi Tu,2 Lingchao Kong,2 Rende Ning1,2 1Graduate School, Bengbu Medical University, Bengbu, Anhui, People’s Republic of China; 2Department of Orthopedics, The Third Affiliated Hospital of Anhui Medical University, The Firs...
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Biphasic behavior of T cell subsets reflects failure of early anti-myeloma response and leads to progressive T cell dysfunction
Published 2025-09-01Subjects: Get full textIntroduction: Multiple Myeloma (MM) progresses over 2-3 decades through two pre-malignant stages (MGUS and SMM), culminating in clinically active disease. Given the limitations in acquiring sequential bone marrow (BM) samples from patients over this time frame, the mechanisms that compromise immunos...
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Dynamic changes in sleep architecture in a mouse model of acute kidney injury transitioning to chronic kidney disease
Published 2025-07-01Subjects: Get full textIntroductionSleep disorders are common in individuals with kidney failure. Whether kidney impairment is the direct cause of sleep abnormalities is unclear, however, partly due to confounding factors including comorbidities, dialysis, and drugs.MethodsHere, we used a mouse model of acute kidney injur...
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PROTECTIVE ACTIVITY STUDY OF A CANDIDATE VACCINE AGAINST ROTAVIRUS INFECTION BASED ON RECOMBINANT PROTEIN FliCVP6VP8
Published 2016-08-01Subjects: Get full textRotavirus infection is among leading causes of severe diarrhea which often leads to severe dehydration, especially, in children under 5 years old. In Russia, the incidence of rotavirus infection is constantly increased, due to higher rates of actual rotavirus infection cases and improved diagnostics...
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The Evolving Landscape of Functional Models of Autism Spectrum Disorder
Published 2025-06-01Subjects: Get full textAutism spectrum disorder (ASD) is a neurodevelopmental disorder affecting 1–3% of the population globally. Owing to its multifactorial origin, complex genetics, and heterogeneity in clinical phenotypes, it is difficult to faithfully model ASD. In essence, ASD is an umbrella term for a group of indiv...
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In vivo microcomputed tomography visualization of a hepatocellular carcinoma orthotopic model using a contrast based on LaF3:Ce(5 %)Tb(15 %) nanoparticles
Published 2025-03-01Subjects: Get full textPurpose of the study. To investigate the effectiveness of a new contrast agent based on LaF3:Ce(5 %)Tb(15 %) nanoparticles on a hepatocellular carcinoma orthotopic model.Materials and methods. The experiment was performed on female BALB/c Nude mice. The subcutaneous model was created by injecting He...
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Impact of Cochlear Trauma Degree and Localization on Intracochlear Electrocochleographic Recordings
Published 2025-06-01Subjects: Get full textBackground/Objectives: Electrocochleography (ECochG) is a promising tool to monitor preservation of cochlear structures and function during cochlear implant (CI) surgery. However, the interpretation of ECochG signal changes during insertion of the CI electrode array remains controversial. This study...
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Integrating weighted gene co-expression network analysis and machine learning to elucidate neural characteristics in a mouse model of depression
Published 2025-06-01Subjects: Get full textIntroductionAn AI-assisted deep learning strategy was applied to analyze the neurobiological characteristics of depression in mouse models. Integration of weighted gene co-expression network analysis (WGCNA) with the random forest algorithm enabled the identification of critical genes strongly assoc...
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Dual‐energy X‐ray absorptiometry for detecting neurogenic pulmonary edema in a mouse model of subarachnoid hemorrhage
Published 2025-06-01Subjects: Get full textAbstract Murine subarachnoid hemorrhage (SAH) induced using the filament perforation method is a useful in vivo experimental model to investigate the pathophysiological mechanisms in the brain underlying SAH. However, identifying mice with comorbid acute neurogenic pulmonary edema (NPE), a life‐thre...
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Allergic contact dermatitis in mice with interleukin-6 deficiency in dendritic cells
Published 2025-06-01Subjects: Get full textContact dermatitis is a disease characterized by skin inflammation caused by external agents, most commonly, allergens. Patients with contact dermatitis have impaired skin barrier function, causing permeability of the epidermis layer. Haptens, including oxazolone, are the small molecules that easily...
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Microfungus <i>Podosphaera fusca</i> and the Fungus-like Organism <i>Peronospora ficariae</i> as Potential Inhalant Allergens in a Mouse Model of Asthma
Published 2025-06-01Subjects: Get full textAllergic conditions have surged to unprecedented levels globally, affecting approximately 30% of the population. Fungi are among the major sources of allergens, accounting for about 6% of respiratory issues. Identifying the causes of respiratory allergies is not always possible. Our study assessed t...
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Vitacrystallography: Appearance and Development of Cancer-Induced Structural Biomarkers in a Mouse Model
Published 2025-06-01Subjects: Get full textStructural biomarkers determined by X-ray scattering of the tissues can complement conventional diagnostics and provide a pathway for early detection of diseases. In the present study, mouse models were utilized to observe the progression of prostate cancer. We induced cancer in the left lobe of the...
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