Search Results - "mitochondrial function"
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Microproteins in Metabolism
Published 2025-06-01Subjects: Get full textMetabolism is a complex network of biochemical pathways that break down macromolecules to produce energy essential for cellular function. Disruptions in metabolic homeostasis are closely linked to noncommunicable diseases (NCDs) such as cardiovascular disease, type 2 diabetes, and cancer, which are...
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Exposure to 6-PPD Quinone Disrupts Adsorption and Catabolism of Leucine and Causes Mitochondrial Dysfunction in <i>Caenorhabditis elegans</i>
Published 2025-06-01Subjects: Get full text6-PPD quinone (6-PPDQ) is a derivative from 6-PPD, an antioxidant added in tires. Leucine is an important amino acid that needs to be obtained from the diet. In <i>Caenorhabditis elegans</i>, we examined the effect of 6-PPDQ exposure at environmentally relevant concentrations (ERCs) on t...
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Vitamin C enhances the in vitro development of early porcine embryos by improving mitochondrial function
Published 2024-12-01Subjects: Get full textMammalian embryos often suffer from oxidative stress in vitro, as the oxygen in the atmosphere is higher than that in the oviductal environment. Vitamin C (Vc) has been proven to enhance early embryonic development in vitro, but the underlying mechanism remains unclear. In this study, we investigate...
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Exercise-induced mitochondrial protection in skeletal muscle of ovariectomized mice: A myogenic E2 synthesis-independent mechanism
Published 2025-09-01Subjects: Get full textBackground: Skeletal muscle, a 17β-estradiol (E2)-sensitive tissue, is prone to accelerated aging due to postmenopausal E2 deficiency and subsequent mitochondrial dysfunction. While exogenous E2 treatment has been shown to protect against mitochondrial damage in ovariectomized rodents, the impact of...
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Advances in in vivo magnetic resonance spectroscopy for metabolic disorders
Published 2025-07-01Subjects: Get full textMagnetic Resonance Spectroscopy (MRS) and Magnetic Resonance Imaging (MRI) yield valuable metabolic information in a non-invasive way. The current mini review addresses current practice and recent advances in metabolic research, specifically in the field of obesity, insulin resistance and diabetes....
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High-intensity interval training improves mitochondrial function and attenuates cardiomyocytes damage in ischemia-reperfusion
Published 2025-10-01Subjects: Get full textIschemic heart disease remains a leading cause of global mortality and morbidity, underscoring the urgent need for effective therapies particularly for patients recovering from ischemic cardiac events. High-intensity interval training (HIIT) has emerged as a promising non-pharmacological interventio...
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Unveiling the Cardioprotective Potential of Hydroxytyrosol: Insights from an Acute Myocardial Infarction Model
Published 2025-06-01Subjects: Get full textCardiovascular diseases remain the leading cause of death worldwide, highlighting the urgent need for novel therapeutic strategies. The Mediterranean diet is renowned for its cardiovascular benefits, largely attributed to extra virgin olive oil (EVOO) and its phenolic compounds, particularly hydroxy...
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DIRAS1 Drives Oxaliplatin Resistance in Colorectal Cancer via PHB1-Mediated Mitochondrial Homeostasis
Published 2025-07-01Subjects: Get full textBackground: Colorectal cancer (CRC) is a prevalent global malignancy with particularly challenging treatment outcomes in advanced stages. Oxaliplatin (OXA) is a frontline chemotherapeutic agent for CRC. However, 15% to 50% of stage III patients experience recurrence due to drug resistance. Elucidati...
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The antioxidant effect of ubiquinone and combined therapy on mitochondrial function in blood cells in non-proliferative diabetic retinopathy: A randomized, double-blind, phase IIa,...
Published 2016-07-01Subjects: Get full textObjectives: To evaluate the effect of ubiquinone and combined antioxidant therapy on mitochondrial function in non-proliferative diabetic retinopathy (NPDR) in a randomized, double-blind, phase IIa, placebo-controlled, clinical trial. Three groups of 20 patients were formed: Group 1, ubiquinone; Gro...
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Impact of SGLT2i on Cardiac Remodeling and the Soleus Muscle of Infarcted Rats
Published 2025-05-01Subjects: Get full textSkeletal muscle changes occur in heart failure (HF). Despite the cardioprotective effects of sodium–glucose co-transporter 2 (SGLT2) inhibitors in HF, their impact on skeletal muscle remains poorly understood. We investigated the effects of the SGLT2 inhibitor empagliflozin (EMPA) on cardiac remodel...
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MitoQ Protects Against Oxidative Stress-Induced Mitochondrial Dysregulation in Human Cardiomyocytes
Published 2025-09-01Subjects: Get full textThe overproduction of reactive oxygen species (ROS) and mitochondrial dysregulation are regarded as key mechanisms in the progression of cardiac remodelling in cardiometabolic diseases including heart failure. Conventional treatments are often ineffective as they do not specifically target the under...
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Arecoline regulates glycolipid and endoplasmic reticulum metabolisms in adult grass carp (Ctenopharyngodon idella)
Published 2025-06-01Subjects: Get full textArecoline is an alkaloid extracted from the plant betel nut with important pharmacological effects and is an agonist at muscarinic receptors (M receptors). In this study, we investigated the effects of dietary arecoline supplementation on hepatopancreatic and muscle glycolipid metabolism in adult gr...
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A novel cross-linked haemoglobin-based oxygen carrier is beneficial to sepsis in rats
Published 2019-12-01Subjects: Get full textPathological hypoxia-induced organ dysfunction contributes to the high mortality of sepsis. Because of the microcirculation dysfunction following severe sepsis, it is difficult for erythrocytes to transport oxygen to hypoxic tissues. Haemoglobin-based oxygen carriers (HBOCs) are capable of deliverin...
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A new peptide inhibitor of C1QBP exhibits potent anti‐tumour activity against triple negative breast cancer by impairing mitochondrial function and suppressing homologous recombina...
Published 2025-01-01Subjects: Get full textAbstract C1QBP exhibits heightened expression across a spectrum of tumours, thereby fostering their proliferation and metastasis, rendering it a pivotal therapeutic target. Nevertheless, to date, no pharmacological agents capable of directly targeting and inducing the degradation of C1QBP have been...
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Roles of 670 nm Photobiomodulation on Rat Anterior Ischemic Optic Neuropathy: Enhancing RGC Survival, Mitochondrial Function, and Anti-Inflammatory Response
Published 2025-07-01Subjects: Get full textNon-arteritic anterior ischemic optic neuropathy (NAION) leads to retinal ganglion cell (RGC) loss and visual impairment, with no effective treatment. This study investigated the neuroprotective effect of 670 nm photobiomodulation (PBM) in a rat NAION model (rNAION). Wistar rats received 670 nm ligh...
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An integrin-based quercetin 7-rhamnoside liver-targeted delivery liposomes for intrahepatic cholestasis in pregnancy
Published 2025-08-01Subjects: Get full textIntrahepatic cholestasis in pregnancy (ICP) is a characteristic disease during the perinatal period; however, its therapy remains unsatisfactory, and the pathogenesis remains unclear. The ameliorative effect of naturally occurring quercetin 7-rhamnoside (Q7R) in cholestasis has been established. In...
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SH3GLB1-related autophagy mediates mitochondrial metabolism to acquire resistance against temozolomide in glioblastoma
Published 2022-07-01Subjects: Get full textAbstract Background The mechanism by which glioblastoma evades temozolomide (TMZ)-induced cytotoxicity is largely unknown. We hypothesized that mitochondria plays a role in this process. Methods RNA transcriptomes were obtained from tumor samples and online databases. Expression of different protein...
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