Search Results - "methotrexate"

Background. A significant advancement in the treatment of high-grade aggressive non-Hodgkin’s lymphomas and acute lymphoblastic leukemia is the inclusion of high-dose (1000–5000 mg/m2) methotrexate in the treatment protocol. This approach has significantly increased the long-term survival rate, but...

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The aim of the study – to analyze the effectiveness and tolerability of subcutaneous methotrexate (sc MTX) (Metorthrit; S.C. Rompharm Company S.R.L) in patients with rheumatoid arthritis (RA) with high disease activity and rapid dose escalation, to assess their quality of life (QoL) in real clinical...

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Osteoarthritis (OA) is a heterogeneous disease with varying degrees of inflammatory responses, structural changes, functional insufficiency, and disease progression as a whole. Some OA phenotypes are characterized by a high local inflammatory response, persistent pain, persistent synovitis, and seve...

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The case report a psoriatic arthritis patient (disfiguring form, high laboratory values, changes of the skin and nails) treated with methotrexate. The drug demonstrated high efficacy resulting in stable sustained remission of articular syndrome, documented both by clinical and laboratory parameters, de...

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Wei-Chong Dong,1,2 Shuai-Shuai Gao,1 Bo Shi,3 Hao-Ran Li,1 Ye Jiang,4,5 Jia-Liang Guo,3 Zhi-Qing Zhang,1 Ying-Ze Zhang2,3 1Department of Pharmacy, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, 050051, People’s Republic of China; 2The School of Medicine, Nankai Univer...

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Objective. Assessment of the efficacy and tolerability of Pentoxifilline (PF) as compared with Methotrexate [ MT> and combination of MT+PF in patients with rheumatoid arthritis (RA). Material and methods. Controlled study of the efficacy and tolerability of MT, PF and their combination was do...

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Hip joint injury, coxitis, is a characteristic manifestation of ankylosing spondylitis. Coxitis therapy has not been elaborated so far. There are few publications on the efficacy of tumor necrosis factor-α inhibitors. Alternative pharmacotherapies, including use of methotrexate, have not fully been...

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Summary Aim of study: Control ofpossible antidestructive effect of low doses of corticosteroids (CS) on the background of basic therapy of rheumatoid arthritis (RA) by methotrexate (MT). Materials and methods: Preliminary results from 38 out of planned 80 patients (all females) aged 23-68 and diseas...

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A bstract. Objective. To study the efficacy and tolerability of Remicade in RA Material and methods. 20 reliable RA pts compatible to criteria for inclusion into the study and without exclusion criteria. 18 women and 2 men aged 30-60 and older wilh disease term from 3 lo 10 years and longer. In 14 p...

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This article presents clinical case of early manifestation of juvenile oligoarthritis with rapid contracture and destructive joint changes formation. Methotrexate was administered IM 15 mg/m2 once a week. After 3 months of treatment — acute inflammatory changes in the joint were relieved as well as...

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Objective: To analyze the results of using methotrexate (MT) in the treatment of psoriasis and psoriatic arthritis (PsA). Results. The mechanism of action of MT, the historical aspects of its use in the treatment of psoriasis and PsA, and the data of clinical trials of the efficacy and safety of the...

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Objective. To study lymphocytes phenotype in rheumatoid arthritis (RA) and its changes during methotrexate (MT) therapy. Methods. 24 RA pts with high clinical and laboratory activity of the disease and 18 healthy donors (control group) were included. All patients received MT 7,5-15 mg/week. They wer...

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The early administration of methotrexate (MTX) and the use of its high (by the rheumatology practice standards) doses contribute to the enhanced efficiency of therapy and the reduced severity of rheumatoid arthritis (RA). One of the important merits of MTX in the treatment of RA is the possibility o...

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<b>Background and Clinical Significance:</b> Implantation of an embryo in the cervical canal is the rarest location of ectopic pregnancy, as it occurs between 1 in 1000 and 1 in 18,000 pregnancies. Dilation and curettage in previous pregnancies have been identified as risk factors in mos...

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The article presents a short review of the current notion of the leading role methotrexate in treatment of most clinical variants ofjuvenile idiopathic arthritis. The authors demonstrate that methotrexate is a “gold standard” of antirheumatic therapy and the key disease-modifying drug of pediatric r...

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The paper reviews the literature on the use of methotrexate (MT) in rheumatoid arthritis (RA) and other rheumatic diseases. The efficacy and tolerability of MT are evaluated. The findings permit its consideration as the gold standard treatment for RA. The main adverse reactions of MT, which are give...

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Dercum disease, also known as painful lipomatosis, neurolipomatosis, Ander’s syndrome, is a rare illness. The main clinical manifestation of this disease is the presence of painful formations of subcutaneous tissue, localized in various parts of the body: on the limbs, trunk, buttocks. Possible etio...

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In our previous publication, we reported the main provisions of the new EULAR recommendations (2013) and discussed some debating points of RA pharmacotherapy that require further research. The purpose of this article is to review the present-day knowledge concerning the use of methotrexate (MT), sin...

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The objective of this study is to conduct a comparative study of the efficacy and safety of methotrexate (MT) at a dose of 10 mg/week and 15 mg/week in patients with pulmonary sarcoidosis having contraindications to GCS therapy. Material and Methods. The study involved 44 patients with stage II pul...

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As new effective biological agents (BAs) are being widely introduced, in the past decade there have been serious changes in the rheumatoid arthritis (RA) strategy: its basis was the treat-to-target concept. It is emphasized that the basic strategy component is active early aggressive therapy with me...

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